Endogenous, descending noradrenergic fibers impose analgesic control over spinal afferent
circuitry mediating the rostrad transmission of pain signals. These fibers target alpha 2 …

Endogenous opiate peptides acting pre-and post-synaptically in the dorsal horn of spinal
cord inhibit transmission of nociceptive stimuli. We transfected neurons of the dorsal root …

The transplantation of cells that secrete neuroactive substances with analgesic properties
into the CNS is a novel method that challenges current approaches in treating chronic pain …

The RN46A cell line was derived from embryonic day 13 rat medullary raphe cells by
infection with a retrovirus encoding the temperature-sensitive mutant of SV40 large T …

In the majority of patients, spinal cord injury (SCI) results in abnormal pain syndromes in
which nonnoxious stimuli become noxious (allodynia). To reduce allodynia, it would be …

Pharmacologic treatment for the symptoms of painful neuropathy has been problematic,
because there has been limited understanding of the underlying etiologies and systemic …

Publisher Summary The mushrooming of the field of cellular transplantation in recent years
has given rise to a new way of supplying analgesic molecules. In animal models, cell …

B16 F1C29 melanoma cells, which are thought to contain and release catecholamines, were
implanted in mouse and rat spinal subarachnoid space. B16 F1C29 cell implants …

Although narcotic analgesics and formulations containing opioids are the most commonly
used agents for the treatment of moderate to severe pain, the use of exogenous drug …

This chapter reviews the cell transplantation strategies that have been explored as potential
options in the treatment of pain and traumatic brain injury (TBI). As the goals of these two …