The halogens chlorine (Cl2) and bromine (Br2) are highly reactive oxidizing elements with
widespread industrial applications and a history of development and use as chemical …

The ion channel TRPA1 is a promiscuous chemosensor, with reported response to a wide
spectrum of noxious electrophilic irritants, as well as cold, heat, and mechanosensation. It is …

Abstract Calcium (Ca 2+) is an essential signaling molecule in all cells. It is involved in
numerous fundamental functions, including cell life and death. Abnormal regulation of Ca 2+ …

Given the high rate of nonresponse or resistance to current inflammatory bowel disease
(IBD) treatments, novel drug targets and biomarkers that aid in therapeutic prediction are …

We have previously proven the involvement of transient receptor potential ankyrin 1
(TRPA1) in stress adaptation. A lack of TRPA1 affects both urocortin 1 (member of the …

Mechanical nociception is essential for animal survival. However, the forces involved in
nociceptor activation and the underlying mechanotransduction mechanisms remain elusive …

Orofacial inflammation leads to transcriptional alterations in trigeminal ganglion (TG)
neurons. However, diverse alterations and regulatory mechanisms following orofacial …

Over the last 17 years since its cloning in 2003, the receptor-channel TRPA1 has received
increasing attention due to its polymodal features and prominent role in pain signaling in a …

Transient receptor potential ankyrin-1 (TRPA1) is an ion channel mediating pain and cough
signals in sensory neurons. We and others have shown that TRPA1 is also expressed in …

Introduction: The centrally projecting Edinger-Westphal nucleus (EWcp) contributes to the
control of alcohol consumption by its urocortin 1 (UCN1) and cocaine-and amphetamine …