The therapeutic potential of non-invasive and invasive cerebellar stimulation techniques in hereditary ataxias

A Benussi, G Batsikadze, C França, RG Cury, RP Maas - Cells, 2023 - mdpi.com
The degenerative ataxias comprise a heterogeneous group of inherited and acquired
disorders that are characterized by a progressive cerebellar syndrome, frequently in …

[HTML][HTML] Cerebellar deep brain stimulation for movement disorders

CH Tai, SH Tseng - Neurobiology of Disease, 2022 - Elsevier
Deep brain stimulation (DBS) conventionally target at basal ganglia or thalamic structures,
modulating nodal points in the cortico-basal ganglia circuit, in order to effectively treat …

Neuromodulation of the cerebellum rescues movement in a mouse model of ataxia

LN Miterko, T Lin, J Zhou, ME van der Heijden… - Nature …, 2021 - nature.com
Deep brain stimulation (DBS) relieves motor dysfunction in Parkinson's disease, and other
movement disorders. Here, we demonstrate the potential benefits of DBS in a model of …

Purkinje cell misfiring generates high-amplitude action tremors that are corrected by cerebellar deep brain stimulation

AM Brown, JJ White, ME van der Heijden, J Zhou, T Lin… - Elife, 2020 - elifesciences.org
Tremor is currently ranked as the most common movement disorder. The brain regions and
neural signals that initiate the debilitating shakiness of different body parts remain unclear …

Advances in DBS technology and novel applications: focus on movement disorders

SR Potel, S Marceglia, S Meoni, SK Kalia… - Current Neurology and …, 2022 - Springer
Abstract Purpose of Review Deep brain stimulation (DBS) is an established treatment in
several movement disorders, including Parkinson's disease, dystonia, tremor, and Tourette …

Safety and outcomes of dentate nucleus deep brain stimulation for cerebellar ataxia

RG Cury, C França, KP Duarte, I Paraguay, JM Diniz… - The Cerebellum, 2021 - Springer
Cerebellar symptoms remain orphan of treatment options despite being prevalent and
incapacitating. Investigate whether dentate nucleus deep brain stimulation (DN DBS) is safe …

[HTML][HTML] Molecular mechanisms and therapeutics for spinocerebellar ataxia type 2

PA Egorova, IB Bezprozvanny - Neurotherapeutics, 2019 - Elsevier
The effective therapeutic treatment and the disease-modifying therapy for spinocerebellar
ataxia type 2 (SCA2)(a progressive hereditary disease caused by an expansion of …

A review of neurophysiological effects and efficiency of waveform parameters in deep brain stimulation

Z Gilbert, X Mason, R Sebastian, AM Tang… - Clinical …, 2023 - Elsevier
Neurostimulation has diverse clinical applications and potential as a treatment for medically
refractory movement disorders, epilepsy, and other neurological disorders. However, the …

[HTML][HTML] A novel naïve Bayes approach to identifying grooming behaviors in the force-plate actometric platform

CJ Anderson, R Cadeddu, DN Anderson… - Journal of Neuroscience …, 2024 - Elsevier
Background Self-grooming behavior in rodents serves as a valuable behavioral index for
investigating stereotyped and perseverative responses. Most current grooming analyses rely …

Investigation of neuromodulatory effect of anodal cerebellar transcranial direct current stimulation on the primary motor cortex using functional near-infrared …

Z Shoaib, WK Chang, J Lee, SH Lee, Z Phillips V… - The Cerebellum, 2024 - Springer
Cerebellar brain inhibition (CBI), a neural connection between the cerebellum and primary
motor cortex (M1), has been researched as a target pathway for neuromodulation to improve …