Simple Summary Novel therapeutic targets are needed to improve treatments of aggressive
cancers and viral diseases. Tetraspanins represent an emerging class of anticancer targets …

There are a plethora of antibiotic resistance cases and humans are marching towards
another big survival test of evolution along with drastic climate change and infectious …

Tetraspanins are an evolutionary conserved family of proteins involved in multiple aspects of
cell physiology, including proliferation, migration and invasion, protein trafficking, and signal …

Mesothelin (MSLN) is a glycoprotein with various expression degrees in different tumors
including mesothelioma, ovarian cancer, pancreatic cancer, etc. MSLN is considered to play …

Therapeutic strategies directed at the tumor surfaceome (TS), including checkpoint inhibitor
blocking antibodies, antibody drug conjugates (ADCs), and chimeric antigen receptor T …

Extracellular vesicles (EVs) are lipid-bound vesicles that originate from the endosomal
system or budded off from the plasma membrane. EVs are involved in cell-cell …

The tetraspanin CD81 was initially discovered by screening mAbs elicited against a human
B cell lymphoma for their direct antiproliferative effects. We now show that 5A6, one of the …

Antibody-secreting cells (ASCs) contribute to immunity through production of antibodies and
cytokines. Identification of specific markers of ASC would allow selective targeting of these …

Abstract Background Cancer-associated fibroblasts (CAFs) have significant tumor regulatory
functions, and CAFs-derived exosomes (CAFs-Exo) released from CAFs play an important …

Prostate cancer is the most prevalent malignant tumor in men across developed countries.
Traditional diagnostic and therapeutic methods for this tumor have become increasingly …