Fluorinated pyrazoles play an important role in medicinal chemistry, drug discovery,
agrochemistry, coordination chemistry, and organometallic chemistry. Since the early 1990s …

2, 2, 2-Trifluorodiazoethane (CF3CHN2) has been proven to be a valuable reagent for the
rapid synthesis of various classes of trifluoromethyl-substituted organic molecules in both …

Carbenes are very important reactive intermediates to access a variety of complex
molecules and are applied widely in organic synthesis and drug discovery. Typically, their …

Pyrazole is an essential structural component of many pharmaceuticals and agrochemicals.
The synthesis of pyrazoles has been a subject of intense research for several decades …

A rapid and modular continuous flow synthesis of highly functionalized fluorinated pyrazoles
and pyrazolines has been developed. Flowing fluorinated amines through sequential …

Although diazoalkanes find regular application in organic synthesis, the synthesis and
application of their fluorinated homologues was long neglected. First described in 1943 …

We disclose an efficient one‐pot transformation of trifluorodiazoethane and higher
perfluorinated homologues with various nitroolefins. This method takes advantage of the …

The dual incorporation of two important functional groups—trifluoromethyl and cyano
moieties into one heterocyclic core in a single-step reaction represents an appealing but …

The development of asymmetric carbene transfer reactions using N-sulfonylhydrazones as
the diazo surrogate is a long-term issue in organic synthesis since N-sulfonylhydrazones …

A Ag-catalyzed three-component annulation protocol, which uses o-alkynylaryl aldehydes,
amines, and trifluorodiazoethane or diazoacetonitrile, to forge a new class of trifluoromethyl …