There is a steadily growing interest in the use of mitochondria as therapeutic agents. The
use of mitochondria derived from mesenchymal stem/stromal cells (MSCs) for therapeutic …

Mitophagy is crucial for maintaining mitochondrial quality. However, its assessment in vivo is
challenging. The endosomal–lysosomal system is a more accessible pathway through …

Mitochondria are dynamic organelles responsible for energy production and cell
metabolism. Disorders in mitochondrial function impair tissue integrity and have been …

Dysfunctional mitochondria are removed via multiple pathways, such as mitophagy, a
selective autophagy process. Here, we identify an intracellular hybrid mitochondria …

Cocaine, an addictive psychostimulant, has a broad mechanism of action, including the
induction of a wide range of alterations in brain metabolism and mitochondrial homeostasis …

Recent evidence supporting that adipose tissue (AT)-derived extracellular vesicles (EVs)
carry an important part of the AT secretome led us to characterize the EV-adipokine profile …

Recent studies have demonstrated that tissue homeostasis and metabolic function are
dependent on distinct tissue-resident immune cells that form functional cell circuits with …

Metabolic diseases, including obesity, diabetes, and nonalcoholic fatty liver disease
(NAFLD), are rising in both incidence and prevalence and remain a major global health and …

The heart is a never-stopping engine that relies on a formidable pool of mitochondria to
generate energy and propel pumping. Because dying cardiomyocytes cannot be replaced …

Extracellular vesicles (EVs) are secreted by all living cells and are found in body fluids. They
exert numerous physiological and pathological functions and serve as cargo shuttles. Due to …