[HTML][HTML] The role of hydrogen therapy in Alzheimer's disease management: Insights into mechanisms, administration routes, and future challenges

J He, F Liu, T Xu, J Ma, H Yu, J Zhao, Y Xie… - Biomedicine & …, 2023 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder predominantly
affecting the elderly. While conventional pharmacological therapies remain the primary …

Mitochondrial Modulators: the defender

E Makinde, L Ma, GD Mellick, Y Feng - Biomolecules, 2023 - mdpi.com
Mitochondria are widely considered the “power hub” of the cell because of their pivotal roles
in energy metabolism and oxidative phosphorylation. However, beyond the production of …

Enhanced mitochondrial targeting and inhibition of pyroptosis with multifunctional metallopolyphenol nanoparticles in intervertebral disc degeneration

H Zhou, Q Qian, Q Chen, T Chen, C Wu, L Chen… - Small, 2024 - Wiley Online Library
Intervertebral disc degeneration (IVDD) is a significant contributor to low back pain,
characterized by excessive reactive oxygen species generation and inflammation‐induced …

Neuroprotective effect of luteolin-7-O-glucoside against 6-OHDA-induced damage in undifferentiated and RA-differentiated SH-SY5Y cells

SCH Rehfeldt, J Silva, C Alves, S Pinteus… - International Journal of …, 2022 - mdpi.com
Luteolin is one of the most common flavonoids present in edible plants and its potential
benefits to the central nervous system include decrease of microglia activation, neuronal …

Glutathione-triggered nanoplatform for chemodynamic/metal-ion therapy

M Liu, H Wu, S Wang, J Hu, B Sun - Journal of Materials Chemistry B, 2021 - pubs.rsc.org
The integration of metal-ion therapy and hydroxyl radical (˙ OH)-mediated chemodynamic
therapy (CDT) holds great potential for anticancer treatment with high specificity and …

[HTML][HTML] Mitochondrion: A bridge linking aging and degenerative diseases

L Zhang, J Wu, Z Zhu, Y He, R Fang - Life Sciences, 2023 - Elsevier
Aging is a natural process, characterized by progressive loss of physiological integrity,
impaired function, and increased vulnerability to death. For centuries, people have been …

Recent advances of small molecule JNK3 inhibitors for Alzheimer's disease

P Qin, Y Ran, Y Liu, C Wei, X Luan, H Niu, J Peng… - Bioorganic …, 2022 - Elsevier
C-Jun N-terminal kinase (JNK) is a member of mitogen-activated protein kinases (MAPKs)
family, with three isoforms, JNK1, JNK2 and JNK3. Alzheimer's disease (AD) is a …

Hydrogen peroxide initiates oxidative stress and proteomic alterations in meningothelial cells

X Xin, T Gong, Y Hong - Scientific Reports, 2022 - nature.com
Meningothelial cells (MECs) are fundamental cells of the sheaths covering the brain and
optic nerve, where they build a brain/optic nerve-cerebral spinal fluid (CSF) barrier that …

[HTML][HTML] Cordycepin protects islet β-cells against glucotoxicity and lipotoxicity via modulating related proteins of ROS/JNK signaling pathway

B Yan, Y Gong, W Meng, H Sun, W Li, K Ding… - Biomedicine & …, 2023 - Elsevier
Type 2 diabetes mellitus (T2DM) is a common and multiple endocrine metabolic disease.
When pancreatic β cell in case of dysfunction, the synthesis and secretion of insulin are …

Oxidative stress induces bovine endometrial epithelial cell damage through mitochondria-dependent pathways

P Song, C Liu, M Sun, J Liu, P Lin, A Wang, Y Jin - Animals, 2022 - mdpi.com
Simple Summary Polymorphonuclear neutrophil (PMN) count is the main diagnostic method
of bovine endometritis. High neutrophil PMN counts in the endometrium of cows affected by …