Making sense of the ageing methylome
Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …
been associated with a broad range of age-related diseases, including cardiovascular …
EWAS Open Platform: integrated data, knowledge and toolkit for epigenome-wide association study
Abstract Epigenome-Wide Association Study (EWAS) has become a standard strategy to
discover DNA methylation variation of different phenotypes. Since 2018, we have developed …
discover DNA methylation variation of different phenotypes. Since 2018, we have developed …
Pyrosequencing: Current forensic methodology and future applications—A review
M Ghemrawi, NF Tejero, G Duncan… - Electrophoresis, 2023 - Wiley Online Library
The recent development of small, single‐amplicon‐based benchtop systems for
pyrosequencing has opened up a host of novel procedures for applications in forensic …
pyrosequencing has opened up a host of novel procedures for applications in forensic …
Prediction of treatment response to antipsychotic drugs for precision medicine approach to schizophrenia: randomized trials and multiomics analysis
Background Choosing the appropriate antipsychotic drug (APD) treatment for patients with
schizophrenia (SCZ) can be challenging, as the treatment response to APD is highly …
schizophrenia (SCZ) can be challenging, as the treatment response to APD is highly …
[HTML][HTML] Prenatal exposure to a wide range of environmental chemicals and child behaviour between 3 and 7 years of age–an exposome-based approach in 5 …
Background Studies looking at associations between environmental chemicals and child
behaviour usually consider only one exposure or family of exposures. Objective This study …
behaviour usually consider only one exposure or family of exposures. Objective This study …
[HTML][HTML] Long-term temporal stability of peripheral blood DNA methylation profiles in patients with inflammatory bowel disease
Background & Aims There is great current interest in the potential application of DNA
methylation alterations in peripheral blood leukocytes (PBLs) as biomarkers of susceptibility …
methylation alterations in peripheral blood leukocytes (PBLs) as biomarkers of susceptibility …
Genome-wide DNA methylation of Munro's microabscess reveals the epigenetic regulation in the pathogenesis of psoriasis
X Xu, Y Zhang, Z Pan, X Zhang, X Liu, L Tang… - Frontiers in …, 2022 - frontiersin.org
Introduction Munro's microabscess is a typical pathological feature in the early psoriatic
lesion, mainly characterized by the accumulation of neutrophils in the epidermis. DNA …
lesion, mainly characterized by the accumulation of neutrophils in the epidermis. DNA …
Tissue-and ethnicity-independent hypervariable DNA methylation states show evidence of establishment in the early human embryo
M Derakhshan, NJ Kessler, M Ishida… - Nucleic acids …, 2022 - academic.oup.com
We analysed DNA methylation data from 30 datasets comprising 3474 individuals, 19
tissues and 8 ethnicities at CpGs covered by the Illumina450K array. We identified 4143 …
tissues and 8 ethnicities at CpGs covered by the Illumina450K array. We identified 4143 …
Discrimination of monozygotic twins using mtDNA heteroplasmy through probe capture enrichment and massively parallel sequencing
Y Zhong, K Zeng, A Adnan, YZ Li, X Hou, Y Pan… - International Journal of …, 2023 - Springer
Differentiating between monozygotic (MZ) twins remains difficult because they have the
same genetic makeup. Applying the traditional STR genotyping approach cannot …
same genetic makeup. Applying the traditional STR genotyping approach cannot …
DNA and protein analyses of hair in forensic genetics
Z Liu, H Simayijiang, Q Wang, J Yang, H Sun… - International Journal of …, 2023 - Springer
Hair is one of the most common pieces of biological evidence found at a crime scene and
plays an essential role in forensic investigation. Hairs, especially non-follicular hairs, are …
plays an essential role in forensic investigation. Hairs, especially non-follicular hairs, are …