Disulfidptosis: disulfide stress–induced cell death
X Liu, L Zhuang, B Gan - Trends in Cell Biology, 2023 - cell.com
The cystine transporter solute carrier family 7 member 11 (SLC7A11)(also known as xCT)
promotes glutathione synthesis and counters oxidative stress–induced cell death, including …
promotes glutathione synthesis and counters oxidative stress–induced cell death, including …
Ferroptosis, radiotherapy, and combination therapeutic strategies
Ferroptosis, an iron-dependent form of regulated cell death driven by peroxidative damages
of polyunsaturated-fatty-acid-containing phospholipids in cellular membranes, has recently …
of polyunsaturated-fatty-acid-containing phospholipids in cellular membranes, has recently …
[HTML][HTML] SLC7A11 expression level dictates differential responses to oxidative stress in cancer cells
The cystine transporter solute carrier family 7 member 11 (SLC7A11; also called xCT)
protects cancer cells from oxidative stress and is overexpressed in many cancers. Here we …
protects cancer cells from oxidative stress and is overexpressed in many cancers. Here we …
Ferroptosis as a mechanism to mediate p53 function in tumor radiosensitivity
Ferroptosis, a form of regulated cell death triggered by lipid peroxidation, was recently
identified as an important mechanism in radiotherapy (RT)-mediated tumor suppression and …
identified as an important mechanism in radiotherapy (RT)-mediated tumor suppression and …
[HTML][HTML] Ferroptosis and ferritinophagy in diabetes complications
Background With long-term metabolic malfunction, diabetes can cause serious damage to
whole-body tissue and organs, resulting in a variety of complications. Therefore, it is …
whole-body tissue and organs, resulting in a variety of complications. Therefore, it is …
Nutritional and metabolic control of ferroptosis
Ferroptosis is a type of regulated cell death characterized by an excessive lipid peroxidation
of cellular membranes caused by the disruption of the antioxidant defense system and/or an …
of cellular membranes caused by the disruption of the antioxidant defense system and/or an …
Iron, ferroptosis, and ischemic stroke
Over 30 million people suffer from the consequences of ischemic stroke. The precise
molecular mechanism of neuronal damage during ischemic stroke remains unclear; …
molecular mechanism of neuronal damage during ischemic stroke remains unclear; …
[HTML][HTML] The role of molecular subtypes and immune infiltration characteristics based on disulfidptosis-associated genes in lung adenocarcinoma
C Qi, J Ma, J Sun, X Wu, J Ding - Aging (Albany NY), 2023 - ncbi.nlm.nih.gov
Lung adenocarcinoma (LUAD) is the most common type of lung cancer which accounts for
about 40% of all lung cancers. Early detection, risk stratification and treatment are important …
about 40% of all lung cancers. Early detection, risk stratification and treatment are important …
SLC7A11 as a gateway of metabolic perturbation and ferroptosis vulnerability in cancer
J Lee, JL Roh - Antioxidants, 2022 - mdpi.com
SLC7A11 is a cell transmembrane protein composing the light chain of system xc−,
transporting extracellular cystine into cells for cysteine production and GSH biosynthesis …
transporting extracellular cystine into cells for cysteine production and GSH biosynthesis …
The ubiquitin–proteasome system links NADPH metabolism to ferroptosis
J Yang, Y Lee, CS Hwang - Trends in Cell Biology, 2023 - cell.com
Ferroptosis is the type of cell death arising from uncontrolled and excessive lipid
peroxidation. NADPH is essential for ferroptosis regulation because it supplies reducing …
peroxidation. NADPH is essential for ferroptosis regulation because it supplies reducing …