Long‐read single molecule real‐time full gene sequencing of cytochrome P450‐2D6
ABSTRACT The cytochrome P450‐2D6 (CYP2D6) enzyme metabolizes∼ 25% of common
medications, yet homologous pseudogenes and copy number variants (CNVs) make …
medications, yet homologous pseudogenes and copy number variants (CNVs) make …
[HTML][HTML] Monitoring Plasmodium vivax resistance to antimalarials: Persisting challenges and future directions
MU Ferreira, TN de Sousa, GW Rangel… - International Journal for …, 2021 - Elsevier
Emerging antimalarial drug resistance may undermine current efforts to control and
eliminate Plasmodium vivax, the most geographically widespread yet neglected human …
eliminate Plasmodium vivax, the most geographically widespread yet neglected human …
PGRNseq: a targeted capture sequencing panel for pharmacogenetic research and implementation
Objectives Although the costs associated with whole-genome and whole-exome next-
generation sequencing continue to decline, they remain prohibitively expensive for large …
generation sequencing continue to decline, they remain prohibitively expensive for large …
Impact of CYP1A2, CYP2C19, and CYP2D6 genotype- and phenoconversion-predicted enzyme activity on clozapine exposure and symptom severity
D Lesche, S Mostafa, I Everall, C Pantelis… - The …, 2020 - nature.com
Clozapine is an atypical antipsychotic metabolized by CYP1A2, CYP2D6, and CYP2C19
enzymes. Among 66 adult schizophrenia patients treated with clozapine-based combination …
enzymes. Among 66 adult schizophrenia patients treated with clozapine-based combination …
Flexible and scalable full‐length CYP2D6 long amplicon PacBio sequencing
HPJ Buermans, RHAM Vossen, SY Anvar… - Human …, 2017 - Wiley Online Library
ABSTRACT Cytochrome P450 2D6 (CYP2D6) is among the most important genes involved
in drug metabolism. Specific variants are associated with changes in the enzyme's amount …
in drug metabolism. Specific variants are associated with changes in the enzyme's amount …
Interrogation of CYP2D6 Structural Variant Alleles Improves the Correlation Between CYP2D6 Genotype and CYP2D6‐Mediated Metabolic Activity
The cytochrome P450 2D6 (CYP 2D6) gene locus is challenging to accurately genotype due
to numerous single nucleotide variants and complex structural variation. Our goal was to …
to numerous single nucleotide variants and complex structural variation. Our goal was to …
Considerations when applying pharmacogenomics to your practice
WT Nicholson, CM Formea, ET Matey, JA Wright… - Mayo Clinic …, 2021 - Elsevier
Many practitioners who have not had pharmacogenomic education are required to apply
pharmacogenomics to their practices. Although many aspects of pharmacogenomics are …
pharmacogenomics to their practices. Although many aspects of pharmacogenomics are …
[HTML][HTML] Multi-site investigation of strategies for the clinical implementation of CYP2D6 genotyping to guide drug prescribing
LH Cavallari, SL Van Driest, CA Prows, JR Bishop… - Genetics in …, 2019 - Elsevier
Purpose A number of institutions have clinically implemented CYP2D6 genotyping to guide
drug prescribing. We compared implementation strategies of early adopters of CYP2D6 …
drug prescribing. We compared implementation strategies of early adopters of CYP2D6 …
Evaluation of the CYP2D6 Haplotype Activity Scores Based on Metabolic Ratios of 4,700 Patients Treated With Three Different CYP2D6 Substrates
The metabolic activity of the polymorphic CYP2D6 enzyme is dependent on the CYP2D6
genotype; however, the guidelines for translating the genotype into phenotype, which are of …
genotype; however, the guidelines for translating the genotype into phenotype, which are of …