Carbamazepine (brand names include Carbatrol, Epitol, Equetro, and Tegretol) is an
effective antiseizure drug that is often used as a first-line agent in the treatment of epilepsy …

Amitriptyline is a tricyclic antidepressant used in the treatment of several psychiatric
disorders, including major depression, obsessive-compulsive disorder, panic attacks …

Objective Antidepressants are frequently prescribed and are the first-line pharmacological
treatments for psychiatric disorders in children and adolescents. Although antidepressants …

Introduction: Pharmacogenomic testing has the potential to greatly benefit patients by
enabling personalization of medication management, ensuring better efficacy and …

Recent reviews suggest that chronic kidney disease (CKD) can affect the pharmacokinetics
of nonrenally eliminated drugs, but the impact of CKD on individual elimination pathways …

Drug response is subject to an important within-and between-individual variability owing,
mainly, to pharmacokinetic and pharmacodynamic factors. Pharmacokinetics includes …

A sensitive and rapid method for determination of loganin, morroniside, catalpol and
acteoside in rat plasma after oral administration of Rehmannia glutinosa Libosch and …

Abstract Cytochrome P450 2D6 (CYP2D6) is an important drug‐metabolizing enzyme
exhibiting extensive interindividual variability predominantly caused by genetic …

Cytochrome P450 2D6 (CYP2D6) is a critical hepatic drug-metabolizing enzyme in humans,
responsible for metabolizing approximately 20%–25% of commonly used medications such …

Introduction: Polypharmacy and genetic variants that strongly influence medication response
(pharmacogenomics, PGx) are two well-described risk factors for adverse drug reactions …