The transmission and processing of pain signals relies critically on the activities of ion
channels that are expressed in afferent pain fibers. This includes voltage-gated channels, as …

Chronic pain is associated with abnormal excitability of the somatosensory system and
remains poorly treated in the clinic. Potassium (K+) channels are crucial determinants of …

KCNQs are voltage-gated K+ channels that control neuronal excitability and are mutated in
epilepsy and autism spectrum disorder (ASD). KCNQs have been extensively studied in …

Electrical excitation of peripheral somatosensory nerves is a first step in generation of most
pain signals in mammalian nervous system. Such excitation is controlled by an intricate set …

The specific functions of sensory systems depend on the tissue-specific expression of genes
that code for molecular sensor proteins that are necessary for stimulus detection and …

Previous studies in several different trigeminal nerve injury/inflammation models indicated
that the hyperexcitability of primary afferent neurons contributes to the pain pathway …

Pathological pain is a hyperexcitability disorder. Since the excitability of a neuron is set and
controlled by a complement of ion channels it expresses, in order to understand and treat …

A majority of people who have sustained spinal cord injury (SCI) experience chronic pain
after injury, and this pain is highly resistant to available treatments. Contusive SCI in rats at …

DNA 5-hydroxylmethylcytosine (5hmC) catalyzed by ten-eleven translocation methylcytosine
dioxygenase (TET) occurs abundantly in neurons of mammals. However, the in vivo causal …

Mesocorticolimbic dopaminergic (DA) neurons have been implicated in regulating
nociception in chronic pain, yet the mechanisms are barely understood. Here, we found that …