Recent large-scale collaborations are generating major surveys of cell types and
connections in the mouse brain, collecting large amounts of data across modalities, spatial …

We have developed workflows to align 3D magnetic resonance histology (MRH) of the
mouse brain with light sheet microscopy (LSM) and 3D delineations of the same specimen …

Cognitive impairment and dementia are recognized as major threats to public health. Many
studies have shown the important role played by challenges to the cerebral vasculature and …

Embryonic neurodevelopment, particularly neural progenitor differentiation into post-mitotic
neurons, has been extensively studied. While the number and composition of post-mitotic …

Genome-wide association studies have demonstrated significant links between human brain
structure and common DNA variants. Similar studies with rodents have been challenging …

MRI has been widely used to probe the neuroanatomy of the mouse brain, directly
correlating MRI findings to histology is still challenging due to the limited spatial resolution …

Diffusion magnetic resonance imaging has been widely used in both clinical and preclinical
studies to characterize tissue microstructure and structural connectivity. The diffusion MRI …

Economic efficiency has been a popular explanation for how networks self-organize within
the developing nervous system. However, the precise nature of the economic negotiations …

Understanding and mapping the human connectome is a long-standing endeavor of
neuroscience, yet the significant challenges associated with the large size of the human …

Information on regional variation in cell numbers and densities in the CNS provides critical
insight into structure, function, and the progression of CNS diseases. However, variability …