Cells encode information in the sequence of biopolymers, such as nucleic acids, proteins,
and glycans. Although glycans are essential to all living organisms, surprisingly little is …

The structural complexity of glycans poses a serious challenge in the chemical synthesis of
glycosides, oligosaccharides and glycoconjugates. Glycan complexity, determined by …

Heparan Sulfate Proteoglycans (HSPGs) are important cell surface and Extracellular Matrix
(ECM) maestros involved in the orchestration of multiple cellular events in physiology and …

Heparin (HP) and heparan sulfate (HS) are linear, anionically charged polysaccharides well-
known for their diverse biological activities. While HP is generally localized in mast cells and …

Heparin and heparan sulfate represent key members of the glycosaminoglycan family of
carbohydrates and underpin considerable repertoires of biological importance. As such …

Glycosaminoglycans (GAGs) are heterogeneous acidic polysaccharides involved in a range
of biological functions. They have a significant influence on the regulation of cellular …

Heparan sulfate (HS) is a complex, polyanionic polysaccharide ubiquitously expressed on
cell surfaces and in the extracellular matrix. HS interacts with numerous proteins to mediate …

Reported herein is a scalable chemical synthesis of disaccharide building blocks for
heparan sulfate (HS) oligosaccharide assembly. The use of d-glucuronate-based acceptors …

Heparan sulfate (HS) has a domain structure in which regions that are modified by
epimerization and sulfonation (NS domains) are interspersed by unmodified fragments (NA …

Chemical synthesis is a powerful tool to access homogeneous complex glycans, which
relies on protecting group (PG) chemistry. However, the overall efficiency of chemical glycan …