From imbalance to impairment: the central role of reactive oxygen species in oxidative stress-induced disorders and therapeutic exploration
S Afzal, AS Abdul Manap, A Attiq… - Frontiers in …, 2023 - frontiersin.org
Increased production and buildup of reactive oxygen species (ROS) can lead to various
health issues, including metabolic problems, cancers, and neurological conditions. Our …
health issues, including metabolic problems, cancers, and neurological conditions. Our …
The relationship of alpha-synuclein to mitochondrial dynamics and quality control
NJ Thorne, DA Tumbarello - Frontiers in molecular neuroscience, 2022 - frontiersin.org
Maintenance of mitochondrial health is essential for neuronal survival and relies upon
dynamic changes in the mitochondrial network and effective mitochondrial quality control …
dynamic changes in the mitochondrial network and effective mitochondrial quality control …
Telomerase-mediated self-assembly of DNA network in cancer cells enabling mitochondrial interference
Y Guo, S Li, Z Tong, J Tang, R Zhang, Z Lv… - Journal of the …, 2023 - ACS Publications
The precise control of the artificially induced reactions inside living cells is emerging as an
effective strategy for the regulation of cell functions. Nevertheless, the manipulation of the …
effective strategy for the regulation of cell functions. Nevertheless, the manipulation of the …
Acquired miR-142 deficit in leukemic stem cells suffices to drive chronic myeloid leukemia into blast crisis
B Zhang, D Zhao, F Chen, D Frankhouser… - Nature …, 2023 - nature.com
The mechanisms underlying the transformation of chronic myeloid leukemia (CML) from
chronic phase (CP) to blast crisis (BC) are not fully elucidated. Here, we show lower levels of …
chronic phase (CP) to blast crisis (BC) are not fully elucidated. Here, we show lower levels of …
Transferred mitochondria accumulate reactive oxygen species, promoting proliferation
CU Kidwell, JR Casalini, S Pradeep, SD Scherer… - Elife, 2023 - elifesciences.org
Recent studies reveal that lateral mitochondrial transfer, the movement of mitochondria from
one cell to another, can affect cellular and tissue homeostasis. Most of what we know about …
one cell to another, can affect cellular and tissue homeostasis. Most of what we know about …
Calorie restriction modulates the transcription of genes related to stress response and longevity in human muscle: The CALERIE study
The lifespan extension induced by 40% caloric restriction (CR) in rodents is accompanied by
postponement of disease, preservation of function, and increased stress resistance. Whether …
postponement of disease, preservation of function, and increased stress resistance. Whether …
Glyphosate-induced mitochondrial reactive oxygen species overproduction activates parkin-dependent mitophagy to inhibit testosterone synthesis in mouse leydig …
L Lu, JB Liu, JQ Wang, CY Lian, ZY Wang… - Environmental Pollution, 2022 - Elsevier
Glyphosate (GLY), one of the most extensively used herbicides in the world, has been
shown to inhibit testosterone synthesis in male animals. Mitochondria are crucial organelles …
shown to inhibit testosterone synthesis in male animals. Mitochondria are crucial organelles …
Synthesis of quercetin functionalized wurtzite type zinc oxide nanoparticles and their potential to regulate intrinsic apoptosis signaling pathway in human metastatic …
V Ramalingam, PM Sathya, T Srivalli, H Mohan - Life Sciences, 2022 - Elsevier
In the present study, the wurtzite (WZ) type of zinc oxide (ZnO) nanoparticles were
synthesized and functionalized with quercetin (ZnO@ Quercetin) for the treatment of ovarian …
synthesized and functionalized with quercetin (ZnO@ Quercetin) for the treatment of ovarian …
Redox activity of flavonoids: Impact on human health, therapeutics, and chemical safety
C Sarkar, P Chaudhary, S Jamaddar… - Chemical Research …, 2022 - ACS Publications
The cost-effectiveness of presently used therapies is a problem in overall redox-based
management, which is posing a significant financial burden on communities across the …
management, which is posing a significant financial burden on communities across the …
Mitochondrial dynamics regulators: implications for therapeutic intervention in cancer
Regardless of the recent advances in therapeutic developments, cancer is still among the
primary causes of death globally, indicating the need for alternative therapeutic strategies …
primary causes of death globally, indicating the need for alternative therapeutic strategies …