From imbalance to impairment: the central role of reactive oxygen species in oxidative stress-induced disorders and therapeutic exploration

S Afzal, AS Abdul Manap, A Attiq… - Frontiers in …, 2023 - frontiersin.org
Increased production and buildup of reactive oxygen species (ROS) can lead to various
health issues, including metabolic problems, cancers, and neurological conditions. Our …

The relationship of alpha-synuclein to mitochondrial dynamics and quality control

NJ Thorne, DA Tumbarello - Frontiers in molecular neuroscience, 2022 - frontiersin.org
Maintenance of mitochondrial health is essential for neuronal survival and relies upon
dynamic changes in the mitochondrial network and effective mitochondrial quality control …

Telomerase-mediated self-assembly of DNA network in cancer cells enabling mitochondrial interference

Y Guo, S Li, Z Tong, J Tang, R Zhang, Z Lv… - Journal of the …, 2023 - ACS Publications
The precise control of the artificially induced reactions inside living cells is emerging as an
effective strategy for the regulation of cell functions. Nevertheless, the manipulation of the …

Acquired miR-142 deficit in leukemic stem cells suffices to drive chronic myeloid leukemia into blast crisis

B Zhang, D Zhao, F Chen, D Frankhouser… - Nature …, 2023 - nature.com
The mechanisms underlying the transformation of chronic myeloid leukemia (CML) from
chronic phase (CP) to blast crisis (BC) are not fully elucidated. Here, we show lower levels of …

Transferred mitochondria accumulate reactive oxygen species, promoting proliferation

CU Kidwell, JR Casalini, S Pradeep, SD Scherer… - Elife, 2023 - elifesciences.org
Recent studies reveal that lateral mitochondrial transfer, the movement of mitochondria from
one cell to another, can affect cellular and tissue homeostasis. Most of what we know about …

Calorie restriction modulates the transcription of genes related to stress response and longevity in human muscle: The CALERIE study

JK Das, N Banskota, J Candia, ME Griswold… - Aging cell, 2023 - Wiley Online Library
The lifespan extension induced by 40% caloric restriction (CR) in rodents is accompanied by
postponement of disease, preservation of function, and increased stress resistance. Whether …

Glyphosate-induced mitochondrial reactive oxygen species overproduction activates parkin-dependent mitophagy to inhibit testosterone synthesis in mouse leydig …

L Lu, JB Liu, JQ Wang, CY Lian, ZY Wang… - Environmental Pollution, 2022 - Elsevier
Glyphosate (GLY), one of the most extensively used herbicides in the world, has been
shown to inhibit testosterone synthesis in male animals. Mitochondria are crucial organelles …

Synthesis of quercetin functionalized wurtzite type zinc oxide nanoparticles and their potential to regulate intrinsic apoptosis signaling pathway in human metastatic …

V Ramalingam, PM Sathya, T Srivalli, H Mohan - Life Sciences, 2022 - Elsevier
In the present study, the wurtzite (WZ) type of zinc oxide (ZnO) nanoparticles were
synthesized and functionalized with quercetin (ZnO@ Quercetin) for the treatment of ovarian …

Redox activity of flavonoids: Impact on human health, therapeutics, and chemical safety

C Sarkar, P Chaudhary, S Jamaddar… - Chemical Research …, 2022 - ACS Publications
The cost-effectiveness of presently used therapies is a problem in overall redox-based
management, which is posing a significant financial burden on communities across the …

Mitochondrial dynamics regulators: implications for therapeutic intervention in cancer

S Kumar, R Ashraf, A CK - Cell biology and toxicology, 2022 - Springer
Regardless of the recent advances in therapeutic developments, cancer is still among the
primary causes of death globally, indicating the need for alternative therapeutic strategies …