The extensive metabolic demands of pregnancy require specific physiological and
anatomical changes. These changes affect almost all organ systems, including the …

Intramuscular injection of long-acting cabotegravir and rilpivirine is a novel, long-acting
antiretroviral therapy (ART) combination approved for use as a fully suppressive regimen for …

Background: Pregnancy is associated with considerable changes in the physiological,
anatomical and biochemical attributes in women. These may alter the exposure to …

Acute and chronic hepatic damages are caused by xenobiotics or different diseases
affecting the liver, characterized by different etiologies and pathological features. It has been …

Aim Peripartum cardiomyopathy (PPCM) can be an initial manifestation of familial dilated
cardiomyopathy (DCM). We aimed to identify mutations in families that could underlie their …

Provides a timely update to a key textbook on human drug metabolism The third edition of
this comprehensive book covers basic concepts of teaching drug metabolism, starting from …

Objective Several studies have demonstrated a favourable safety profile for thiopurine use
for inflammatory bowel disease (IBD) during pregnancy. We performed a study in pregnant …

An increasing and early-onset use of immunosuppressives and biologics has become more
frequently seen among patients with inflammatory bowel diseases (IBD) and rheumatic …

Background: Animal and human experiments have confirmed sex differences in the
expression of hepatic enzymes that metabolize antipsychotic drugs and that may, in this …

The placenta plays a critical role in mammalian reproduction. Although it is a transient
organ, its function is indispensable to communication between the mother and fetus, and …