Infantile spasms is a unique disorder peculiar to infancy and early childhood. In this article,
the clinical manifestations and electroencephalographic features of the disorder are …

We postulate that “system epilepsies”(SystE) are due to an enduring propensity to generate
seizures of functionally characterized brain systems. Data supporting this hypothesis—that …

Ohtahara syndrome and early myoclonic encephalopathy are the earliest presenting of the
epileptic encephalopathies. They are typically distinguished from each other according to …

Infantile spasms are characterized by age-specific expression of epileptic spasms and
hypsarrhythmia and often result in significant cognitive impairment. Other epilepsies or …

GABA ergic interneurons control the neural circuitry and network activity in the brain. The
advances in genetics have identified genes that control the development, maturation, and …

Infantile spasms is a severe epileptic encephalopathy of infancy. The fundamental cause is
unknown, although a number of predisposing conditions are recognized. In this article, the …

Relevant to the definition of epileptic encephalopathy (EE) is the concept that the epileptic
activity itself may contribute to bad outcomes, both in terms of epilepsy and cognition, above …

Objective Approximately 50% of patients with tuberous sclerosis complex develop infantile
spasms, a sudden onset epilepsy syndrome associated with poor neurological outcomes …

The mechanisms of epileptogenesis in pediatric epileptic syndromes are diverse, and may
involve disturbances of neurodevelopmental trajectories, synaptic homeostasis, and cortical …

Purpose: Infantile spasms is one of the most severe epileptic syndromes of infancy and early
childhood. Progress toward understanding the pathophysiology of this disorder and the …