Adenosine A2A-dopamine D2 receptor interactions play a very important role in striatal
function. A2A-D2 receptor interactions provide an example of the capabilities of information …

Adenosine is a naturally occurring nucleoside that is distributed ubiquitously throughout the
body as a metabolic intermediary. In the brain, adenosine functions as an important …

G protein‐coupled receptors are known to form homo‐and heteromers at the plasma
membrane, but the stoichiometry of these receptor oligomers are relatively unknown. Here …

Plasticity of excitatory synapses onto striatal projection neurons (MSNs) has the potential to
regulate motor function by setting the gain on signals driving both direct-and indirect …

A2A adenosine receptor antagonists are currently under investigation as potential
therapeutic agents for Parkinson's disease (PD). However, the molecular mechanisms …

Comorbidities in Neurology represent a major conceptual and therapeutic challenge. For
example, temporal lobe epilepsy (TLE) is a syndrome comprised of epileptic seizures and …

Cognitive impairments in Huntington's disease (HD) are attributed to a dysfunction of the
cortico-striatal pathway and significantly affect the quality of life of the patients, but this has …

Dopamine contributes to corticostriatal plasticity and motor learning. Dopamine denervation
profoundly alters motor performance, as in Parkinson's disease (PD); however, the extent to …

Addiction is characterized by a persistent loss of behavioral control resulting in insensitivity
to negative feedback and abnormal decision‐making. Here, we investigated the influence of …

Parkinson's disease (PD) is a debilitating neurodegenerative disorder associated with
severe motor impairments caused by the loss of dopaminergic innervation of the striatum …