Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases
AE Kane, DA Sinclair - Circulation research, 2018 - Am Heart Assoc
The sirtuin family of nicotinamide adenine dinucleotide–dependent deacylases (SIRT1–7)
are thought to be responsible, in large part, for the cardiometabolic benefits of lean diets and …
are thought to be responsible, in large part, for the cardiometabolic benefits of lean diets and …
[HTML][HTML] Quantitative analysis of NAD synthesis-breakdown fluxes
The redox cofactor nicotinamide adenine dinucleotide (NAD) plays a central role in
metabolism and is a substrate for signaling enzymes including poly-ADP-ribose …
metabolism and is a substrate for signaling enzymes including poly-ADP-ribose …
Niacin cures systemic NAD+ deficiency and improves muscle performance in adult-onset mitochondrial myopathy
E Pirinen, M Auranen, NA Khan, V Brilhante, N Urho… - Cell metabolism, 2020 - cell.com
NAD+ is a redox-active metabolite, the depletion of which has been proposed to promote
aging and degenerative diseases in rodents. However, whether NAD+ depletion occurs in …
aging and degenerative diseases in rodents. However, whether NAD+ depletion occurs in …
NAD+ homeostasis in human health and disease
R Zapata‐Pérez, RJA Wanders… - EMBO molecular …, 2021 - embopress.org
Depletion of nicotinamide adenine dinucleotide (NAD+), a central redox cofactor and the
substrate of key metabolic enzymes, is the causative factor of a number of inherited and …
substrate of key metabolic enzymes, is the causative factor of a number of inherited and …
NAD+ supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency
Emerging findings suggest that compromised cellular bioenergetics and DNA repair
contribute to the pathogenesis of Alzheimer's disease (AD), but their role in disease-defining …
contribute to the pathogenesis of Alzheimer's disease (AD), but their role in disease-defining …
NAD+ in aging: molecular mechanisms and translational implications
The coenzyme NAD+ is critical in cellular bioenergetics and adaptive stress responses. Its
depletion has emerged as a fundamental feature of aging that may predispose to a wide …
depletion has emerged as a fundamental feature of aging that may predispose to a wide …
NAD+ homeostasis in renal health and disease
KM Ralto, EP Rhee, SM Parikh - Nature Reviews Nephrology, 2020 - nature.com
The mammalian kidney relies on abundant mitochondria in the renal tubule to generate
sufficient ATP to provide the energy required for constant reclamation of solutes from crude …
sufficient ATP to provide the energy required for constant reclamation of solutes from crude …
[HTML][HTML] Sarcopenia and muscle aging: a brief overview
The world is facing the new challenges of an aging population, and understanding the
process of aging has therefore become one of the most important global concerns …
process of aging has therefore become one of the most important global concerns …
[HTML][HTML] Nicotinamide improves aspects of healthspan, but not lifespan, in mice
The role in longevity and healthspan of nicotinamide (NAM), the physiological precursor of
NAD+, is elusive. Here, we report that chronic NAM supplementation improves healthspan …
NAD+, is elusive. Here, we report that chronic NAM supplementation improves healthspan …
Nicotinamide riboside—the current state of research and therapeutic uses
M Mehmel, N Jovanović, U Spitz - Nutrients, 2020 - mdpi.com
Nicotinamide riboside (NR) has recently become one of the most studied nicotinamide
adenine dinucleotide (NAD+) precursors, due to its numerous potential health benefits …
adenine dinucleotide (NAD+) precursors, due to its numerous potential health benefits …