Skeletal muscle function declines in the aging process or disease; however, until now,
skeletal muscle has remained one of the organs most undertreated with medication. In this …

Mutations in the dystrophin gene cause Duchenne muscular dystrophy (DMD), a common
muscle disease that manifests with muscle weakness, wasting, and degeneration. An …

The nicotinamide adenine dinucleotide (NAD+) precursor nicotinamide mononucleotide
(NMN) is a proposed therapy for age‐related disease, whereby it is assumed that NMN is …

Introduction We have previously demonstrated that a pathologic downregulation of
peroxisome proliferator-activated receptor–gamma coactivator 1-alpha (PGC1α) within the …

In humans, chronic glucocorticoid use is associated with side effects like muscle wasting,
obesity, and metabolic syndrome. Intermittent steroid dosing has been proposed in …

The nicotinamide adenine dinucleotide (NAD+) is an essential redox cofactor, involved in
various physiological and molecular processes, including energy metabolism, epigenetics …

Supplementation with NAD precursors such as nicotinamide riboside (NR) has been shown
to enhance mitochondrial function in the liver and to prevent hepatic lipid accumulation in …

Objective Liver fibrosis is part of the non-alcoholic fatty liver disease (NAFLD) spectrum,
which currently has no approved pharmacological treatment. In this study, we investigated …

Nicotinamide adenine dinucleotide (NAD+) is a ubiquitous metabolite that serves an
essential role in the catabolism of nutrients. Recently, there has been a surge of interest in …

Nonalcoholic steatohepatitis (NASH) is the most common chronic liver disease in the US,
partly due to the increasing incidence of metabolic syndrome, obesity, and type 2 diabetes …