Cu-related agents for cancer therapies

C Wang, X Yang, C Dong, K Chai, J Ruan… - Coordination Chemistry …, 2023 - Elsevier
As an indispensable micronutrient, copper (Cu) plays an important role in promoting
metabolism and maintaining various basic biological functions. Copper homeostasis in the …

Transition metal complexes with tridentate schiff bases (ONO and ONN) derived from salicylaldehyde: an analysis of their potential anticancer activity

LA Alfonso‐Herrera, S Rosete‐Luna… - …, 2022 - Wiley Online Library
Although it is known that the first case of cancer was recorded in ancient Egypt around 1600
BC, it was not until 1917 during the First World War and the development of mustard gas that …

Synthesis, characterization, crystal structure, Hirshfeld surface analysis and DFT of 1, 2-benzothiazine metal (II) complexes

S Zainab, WA Siddiqui, MA Raza, A Ashraf… - Journal of Molecular …, 2023 - Elsevier
In the present study, the mononuclear complexes of oxicam precursor with Mn (II), Co (II), Ni
(II), Cu (II) and Zn (II) metal ions have been prepared. The UV/Vis, FT-IR, 1 H NMR …

[HTML][HTML] The importance of being Casiopeina as polypharmacologycal profile (mixed chelate–copper (II) complexes and their in vitro and in vivo activities)

Z Aguilar-Jiménez, A Espinoza-Guillén… - Inorganics, 2023 - mdpi.com
In this review, we present a timeline that shows the origin of mixed chelate copper (II)
complexes, registered as Mark Title Casiopeínas®, as the first copper (II) compounds …

[HTML][HTML] New Copper (II)-L-dipeptide-bathophenanthroline complexes as potential anticancer agents—synthesis, characterization and cytotoxicity studies—and …

CY Fernández, N Alvarez, A Rocha, J Ellena… - Molecules, 2023 - mdpi.com
Searching for new copper compounds which may be useful as antitumor drugs, a series of
new [Cu (L-dipeptide)(batho)](batho: 4, 7-diphenyl-1, 10-phenanthroline, L-dipeptide: Gly …

Biological activity of mixed chelate copper (II) complexes, with substituted diimine and tridentate Schiff bases (NNO) and their hydrogenated derivatives as secondary …

CS Novoa-Ramírez, A Silva-Becerril… - Journal of Inorganic …, 2023 - Elsevier
We synthesize and characterize nine copper (II) compounds. Four with general formula [Cu
(NNO)(NO 3)] and five mixed chelates [Cu (NNO)(NN)]+, where NNO corresponds to …

[HTML][HTML] The Anti-Leishmania amazonensis and Anti-Leishmania chagasi Action of Copper(II) and Silver(I) 1,10-Phenanthroline-5,6-dione Coordination Compounds

SSC Oliveira, VS Santos, M Devereux, M McCann… - Pathogens, 2023 - mdpi.com
Leishmaniasis is a neglected disease caused by protozoa belonging to the Leishmania
genus. Notably, the search for new, promising and potent anti-Leishmania compounds …

Structural, Vibrational, Thermal, and Cytotoxic Characterization of Aqua (1, 10‐Phenanthroline)(L‐Serinato) Copper (II) Nitrate Complex Combined with DFT …

MC Ramos, JG de Oliveira Neto… - Crystal Research …, 2023 - Wiley Online Library
In this study, X‐ray diffraction confirms the crystallization of aqua (1, 10‐phenanthroline)(L‐
serinato) copper (II) nitrate in the triclinic system (P‐1). Density functional theory calculations …

Copper (II) complexes with 4-(diethylamino) salicylaldehyde and α-diimines: Anticancer, antioxidant, antigenotoxic effects and interaction with DNA and albumins

T Vitomirov, F Dimiza, IZ Matić, T Stanojković… - Journal of Inorganic …, 2022 - Elsevier
In this article, cytotoxicity, the mechanisms of cytotoxic activity, genotoxicity, and interaction
with DNA and proteins, of two Cu (II) complexes with a salicylaldehyde derivative (4 …

[HTML][HTML] Thermodynamics-based rules of thumb to evaluate the interaction of chelators and kinetically-labile metal ions in blood serum and plasma

E Falcone, P Faller - Dalton Transactions, 2023 - pubs.rsc.org
Metal ions play a very important role in nature and their homeostasis is crucial. A lot of metal-
related chemical research activities are ongoing that concern metal-based drugs or tools …