[HTML][HTML] Emerging concepts of miRNA therapeutics: from cells to clinic

C Diener, A Keller, E Meese - Trends in Genetics, 2022 - cell.com
MicroRNAs (miRNAs) are very powerful genetic regulators, as evidenced by the fact that a
single miRNA can direct entire cellular pathways via interacting with a broad spectrum of …

[HTML][HTML] Circular RNAs: new layer of complexity evading breast cancer heterogeneity

A Dawoud, ZI Zakaria, HH Rashwan… - Non-Coding RNA …, 2023 - Elsevier
Advances in high-throughput sequencing techniques and bioinformatic analysis have
refuted the “junk” RNA hypothesis that was claimed against non-coding RNAs (ncRNAs) …

[HTML][HTML] Circular RNAs as potential biomarkers in breast cancer

FDE De Palma, F Salvatore, JG Pol, G Kroemer… - Biomedicines, 2022 - mdpi.com
Due to the high heterogeneity and initially asymptomatic nature of breast cancer (BC), the
management of this disease depends on imaging together with immunohistochemical and …

[HTML][HTML] The tumorigenic role of circular RNA-MicroRNA Axis in cancer

WR Kim, EG Park, DH Lee, YJ Lee, WH Bae… - International Journal of …, 2023 - mdpi.com
Circular RNAs (circRNAs) are a class of endogenous RNAs that control gene expression at
the transcriptional and post-transcriptional levels. Recent studies have increasingly …

[HTML][HTML] Exosomal circular RNAs: New player in breast cancer progression and therapeutic targets

BM Hussen, S Mohamadtahr, SR Abdullah… - Frontiers in …, 2023 - frontiersin.org
Breast cancer is the most prevalent type of malignancy among women. Exosomes are
extracellular vesicles of cell membrane origin that are released via exocytosis. Their cargo …

[HTML][HTML] Non-Coding RNAs: Foes or Friends for Targeting Tumor Microenvironment

A Szymanowska, C Rodriguez-Aguayo… - Non-coding RNA, 2023 - mdpi.com
Non-coding RNAs (ncRNAs) are a group of molecules critical for cell development and
growth regulation. They are key regulators of important cellular pathways in the tumor …

[HTML][HTML] miRNAs in regulation of tumor microenvironment, chemotherapy resistance, immunotherapy modulation and miRNA therapeutics in cancer

K Kousar, T Ahmad, MS Abduh, B Kanwal… - International Journal of …, 2022 - mdpi.com
miRNAs are 20–22 long nucleotide non-coding ribonucleic acid molecules critical to the
modulation of molecular pathways. Immune evasion and the establishment of a suitable …

[HTML][HTML] Transcriptomics-based liquid biopsy panel for early non-invasive identification of peritoneal recurrence and micrometastasis in locally advanced gastric …

P Ding, H Wu, J Wu, T Li, R Gu, L Zhang… - Journal of Experimental …, 2024 - Springer
Background This study aimed to develop a novel six-gene expression biomarker panel to
enhance the early detection and risk stratification of peritoneal recurrence and …

[HTML][HTML] Circular RNAs in EMT-driven metastasis regulation: modulation of cancer cell plasticity, tumorigenesis and therapy resistance

M Ashrafizadeh, J Dai, P Torabian, N Nabavi… - Cellular and Molecular …, 2024 - Springer
The non-coding RNAs comprise a large part of human genome lack of capacity in encoding
functional proteins. Among various members of non-coding RNAs, the circular RNAs …

[HTML][HTML] Mimic miRNA and Anti-miRNA Activated Scaffolds as a Therapeutic Strategy to Promote Bone, Cartilage, and Skin Regeneration

G Guelfi, C Capaccia, P Anipchenko, F Ciancabilla… - Macromol, 2024 - mdpi.com
MiRNA-based therapies represent an innovative and promising strategy applicable to
various medical fields, such as tissue regeneration and the treatment of numerous diseases …