Tetrazole derivatives are a prime class of heterocycles, very important to medicinal
chemistry and drug design due to not only their bioisosterism to carboxylic acid and amide …

OBJECTIVE: To review the progress in developing direct thrombin inhibitors (DTIs) for
anticoagulation within the context of existing anticoagulation therapies. DATA SOURCES …

The activities of inhibitors (Æ)-1 and (Æ)-2 were tested, as previously described,[7] towards
thrombin, the digestive enzyme trypsin, and two other serine proteases from the blood …

1, 5-Disubstituted tetrazoles are an important drug-like scaffold known for their ability to
mimic the cis-amide bond conformation. The scaffold is readily accessible via substitution of …

Thromboembolic diseases are the leading causes of morbidity and mortality in the
developed world. Anticoagulants provide effective treatment for venous or arterial …

Venous and arterial thromboembolism are a major cause for morbidity and mortality. The list
of established drugs for the prevention of thrombus formation and embolisation includes …

Heparan sulfate glycosaminoglycans (HSGAGs) are involved in tumor cell growth, adhesion,
invasion, and migration, due to their interactions with various proteins. In this study, novel …

A two-step, fully automatic virtual screening procedure consisting of flexible docking
followed by activity prediction by COMparative BINding Energy (COMBINE) analysis is …

A short and efficient synthesis of 4-aminomethyl-4-fluoropiperidines and 3-aminomethyl-3-
fluoropyrrolidines is described. These fluorinated azaheterocycles are of specific interest as …

Based on the both of results for X-ray studies of tetrahydrothiazolopyridine derivative 1c and
FXV673, we synthesized a series of thiazol-5-ylpyridine derivatives containing pyridine N …