Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes

BS Karam, A Chavez-Moreno, W Koh, JG Akar… - Cardiovascular …, 2017 - Springer
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in humans. Several
risk factors promote AF, among which diabetes mellitus has emerged as one of the most …

Statins and cardiovascular diseases: from cholesterol lowering to pleiotropy

Q Zhou, JK Liao - Current pharmaceutical design, 2009 - ingentaconnect.com
Statins are 3-hydroxy-3-methyglutaryl coenzyme A (HMG-CoA) reductase inhibitors, which
are prescribed extensively for cholesterol lowering in the primary and secondary prevention …

The role of oxidative stress in the pathogenesis and perpetuation of atrial fibrillation

P Korantzopoulos, TM Kolettis, D Galaris… - International journal of …, 2007 - Elsevier
Atrial fibrillation (AF) is the most common arrhythmia encountered in clinical practice
representing a major health hazard. Owing to relative inefficacy and side effects of classic …

Antiarrhythmic effect of statin therapy and atrial fibrillation: a meta-analysis of randomized controlled trials

L Fauchier, B Pierre, A de Labriolle, C Grimard… - Journal of the American …, 2008 - jacc.org
Objectives: To improve the evaluation of the possible antiarrhythmic effect of statins, we
performed a meta-analysis of randomized trials with statins on the end point of incidence or …

Update on the association of inflammation and atrial fibrillation

P Patel, H Dokainish, P Tsai… - Journal of cardiovascular …, 2010 - Wiley Online Library
Update on the Association of Inflammation and Atrial Fibrillation. Atrial fibrillation (AF) is a
common arrhythmia and is associated with significant morbidity and mortality. The …

Statin use and development of atrial fibrillation: a systematic review and meta-analysis of randomized clinical trials and observational studies

T Liu, L Li, P Korantzopoulos, E Liu, G Li - International journal of …, 2008 - Elsevier
BACKGROUND: Inflammation and oxidative stress have been associated with AF. On the
other hand, accumulating evidence suggests that statins may have antiarrhythmic effects …

Do statins have an antiarrhythmic activity?

MS Kostapanos, EN Liberopoulos… - Cardiovascular …, 2007 - academic.oup.com
Sudden cardiac death, which is mainly associated with the presence of life-threatening
ventricular arrhythmias, is a common 'killer'among patients with coronary artery disease …

Prevention of atrial fibrillation with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors

O Adam, HR Neuberger, M Böhm, U Laufs - Circulation, 2008 - Am Heart Assoc
Methods A systematic literature search was conducted to identify studies evaluating
pharmacological strategies to prevent AF published between 1966 and November 2007 …

Reactive oxidative metabolites are associated with atrial conduction disturbance in patients with atrial fibrillation

M Shimano, R Shibata, Y Inden, N Yoshida… - Heart rhythm, 2009 - Elsevier
BACKGROUND: Oxidative stress is associated with atrial fibrillation (AF). However, little is
known about the relationship between serum markers of oxidation and electrical activity in …

Nonantiarrhythmic drug therapy for atrial fibrillation

KT Murray, LC Mace, Z Yang - Heart rhythm, 2007 - Elsevier
Recent studies have begun to elucidate the molecular mechanisms that promote the
generation and progressive nature of atrial fibrillation. Evidence from both experimental and …