[HTML][HTML] Impact of dendrimers on solubility of hydrophobic drug molecules
Adequate aqueous solubility has been one of the desired properties while selecting drug
molecules and other bio-actives for product development. Often solubility of a drug …
molecules and other bio-actives for product development. Often solubility of a drug …
Overcoming poor oral bioavailability using nanoparticle formulations–opportunities and limitations
Oral delivery of drugs with poor aqueous solubility and poor enzymatic and/or metabolic
stability is very challenging. However, the advent of nanotechnology has revolutionized the …
stability is very challenging. However, the advent of nanotechnology has revolutionized the …
Recent trends of self-emulsifying drug delivery system for enhancing the oral bioavailability of poorly water-soluble drugs
P Tran, JS Park - Journal of Pharmaceutical Investigation, 2021 - Springer
Background The oral route is the most popular route for the clinical administration of drugs to
treat various diseases. Before a drug is absorbed into the blood circulation, it must undergo …
treat various diseases. Before a drug is absorbed into the blood circulation, it must undergo …
[HTML][HTML] Design, optimization and evaluation of glipizide solid self-nanoemulsifying drug delivery for enhanced solubility and dissolution
RN Dash, H Mohammed, T Humaira… - Saudi Pharmaceutical …, 2015 - Elsevier
A solid self-nanoemulsifying drug-delivery system (solid SNEDDS) has been explored to
improve the solubility and dissolution profile of glipizide. SNEDDS preconcentrate was …
improve the solubility and dissolution profile of glipizide. SNEDDS preconcentrate was …
Development and in vitro/in vivo performance of self-nanoemulsifying drug delivery systems loaded with candesartan cilexetil
Candesartan cilexetil is widely used in the management of hypertension and heart failure.
The drug delivery encounters obstacles of poor aqueous solubility, efflux by intestinal P …
The drug delivery encounters obstacles of poor aqueous solubility, efflux by intestinal P …
Improving oral absorption via drug-loaded nanocarriers: absorption mechanisms, intestinal models and rational fabrication
MA Shahbazi, HA Santos - Current drug metabolism, 2013 - ingentaconnect.com
Although it is acknowledged that the main impediment of orally administered therapeutic
agents is their extensive and changeable pre-systemic metabolism, low absorption and …
agents is their extensive and changeable pre-systemic metabolism, low absorption and …
Improving The oral absorption of nintedanib by a self-microemulsion drug delivery system: preparation and in vitro/in vivo evaluation
H Liu, J Mei, Y Xu, L Tang, D Chen, Y Zhu… - International Journal …, 2019 - Taylor & Francis
Objective Nintedanib (NDNB) is a triple receptor tyrosine kinase inhibitor with poor solubility
in neutral conditions and low bioavailability. A self-microemulsifying drug delivery system …
in neutral conditions and low bioavailability. A self-microemulsifying drug delivery system …
Calculation of drug-polymer mixing enthalpy as a new screening method of precipitation inhibitors for supersaturating pharmaceutical formulations
Supersaturating formulations are widely used to improve the oral bioavailability of poorly
soluble drugs. However, supersaturated solutions are thermodynamically unstable and such …
soluble drugs. However, supersaturated solutions are thermodynamically unstable and such …
Quality-by-design strategy for the development of arteether loaded solid self-micro emulsifying drug delivery systems
N Bajwa, S Naryal, S Mahal, PA Singh… - Journal of Drug Delivery …, 2022 - Elsevier
The present work is conducted to develop the innovative micro sized solid oral dosage forms
of Arteether using a Quality by Design technique to increase the solubility and …
of Arteether using a Quality by Design technique to increase the solubility and …
[PDF][PDF] Formulation and characterization of nimodipine nanoemulsion as ampoule for oral route
MM Ghareeb, AJ Neamah - International Journal of …, 2017 - researchgate.net
The aim of this study was to develop oil in water nanoemulsion of nimodipine intended for
oral use. Nimodipine is a calcium channel blocker that has poor oral bioavailability (3-30%) …
oral use. Nimodipine is a calcium channel blocker that has poor oral bioavailability (3-30%) …