Traumatic Brain Injury (TBI) remains a major cause of disability worldwide. It involves a
complex neurometabolic cascade, including oxidative stress. The products of this …

There are several interrelated mechanisms involving iron, dopamine, and neuromelanin in
neurons. Neuromelanin accumulates during aging and is the catecholamine-derived …

Iron dysregulation has been implicated in multiple neurodegenerative diseases, including
Parkinson's disease (PD). Iron-loaded microglia are frequently found in affected brain …

Iron dyshomeostasis can cause neuronal damage to iron-sensitive brain regions.
Neurodegeneration with brain iron accumulation reflects a group of disorders caused by iron …

Iron is an essential micronutrient that is problematic for biological systems since it is toxic as
it generates free radicals by interconverting between ferrous (Fe 2+) and ferric (Fe 3+) forms …

The concept of central nervous system (CNS) inflammation has evolved over the last
decades. Neuroinflammation is the response of reactive CNS components to altered …

With the industrial development and progressive increase in environmental pollution, the
mankind overexposure to heavy metals emerges as a pressing public health issue …

Iron is a critical element for most organisms, which plays a fundamental role in the great
majority of physiological processes. So much so, that disruption of iron homeostasis has …

Iron is the most abundant trace element in the human body. It is well known that iron is an
important component of hemoglobin involved in the transport of oxygen. As a component of …

A growing set of observations points to mitochondrial dysfunction, iron accumulation,
oxidative damage and chronic inflammation as common pathognomonic signs of a number …