Protein liquid–liquid phase separation (LLPS) plays a crucial role in mediating dynamic
assembly of different membraneless organelles such as stress granules (SGs) …

Mutations in genes that encode RNA-binding proteins (RBPs) have emerged as critical
determinants of neurological diseases, especially motor neuron disorders such as …

The neurodegenerative diseases are a diverse group of disorders characterized by
progressive loss of specific groups of neurons. These diseases affect different populations …

Amyotrophic lateral sclerosis (ALS) is a genetically diverse disease. At least 15 ALS-
associated gene loci have so far been identified, and the causative gene is known in …

Biomolecular condensation arising through phase transitions has emerged as an essential
organizational strategy that governs many aspects of cell biology. In particular, the role of …

Hexanucleotide repeat expansions in C9orf72 are the most common cause of amyotrophic
lateral sclerosis (ALS) and frontotemporal degeneration (FTD)(c9ALS/FTD). Unconventional …

Why do cells age? Recent advances show that the cytoplasm is organized into many
membrane‐less compartments via a process known as phase separation, which ensures …

Amyotrophic lateral sclerosis (ALS) is the most common adult-onset motor neuron disease
and is characterized by the degeneration of upper and lower motor neurons. It has become …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of motor neurons
leading to death from respiratory failure within about 3 years of symptom onset. A family …

Frontotemporal dementia (FTD) is a clinical syndrome with a heterogeneous molecular
basis. Until recently, the underlying cause was known in only a minority of cases that were …