Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are
relentlessly progressive neurodegenerative disorders with overlapping clinical, genetic and …

The RNA-binding protein FUS/TLS, mutation in which is causative of the fatal motor neuron
disease amyotrophic lateral sclerosis (ALS), is demonstrated to directly bind to the U1 …

The RNA-binding proteins TDP-43 and FUS form abnormal cytoplasmic aggregates in
affected tissues of patients with amyotrophic lateral sclerosis and frontotemporal lobar …

Frontotemporal dementia (FTD), the second most common form of dementia in people under
65 years of age, is characterized by progressive atrophy of the frontal and/or temporal lobes …

Defective FUS metabolism is strongly associated with amyotrophic lateral sclerosis and
frontotemporal dementia (ALS/FTD), but the mechanisms linking FUS to disease are not …

Local regulation of protein synthesis in neurons has emerged as a leading research focus
because of its importance in synaptic plasticity and neurological diseases. The complexity of …

Mutations in the gene encoding Fused in Sarcoma (FUS) cause amyotrophic lateral
sclerosis (ALS), a fatal neurodegenerative disorder. FUS is a predominantly nuclear DNA …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder involving
both upper motor neurons (UMN) and lower motor neurons (LMN). Enormous research has …

FUS is a nuclear RNA-binding protein, and its cytoplasmic aggregation is a pathogenic
signature of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). It …

Interest in RNA dysfunction in amyotrophic lateral sclerosis (ALS) recently aroused upon
discovering causative mutations in RNA‐binding protein genes. Here, we show that …