The endocannabinoid system as an emerging target of pharmacotherapy

P Pacher, S Bátkai, G Kunos - Pharmacological reviews, 2006 - ASPET
The recent identification of cannabinoid receptors and their endogenous lipid ligands has
triggered an exponential growth of studies exploring the endocannabinoid system and its …

Cannabinoids as novel anti-inflammatory drugs

P Nagarkatti, R Pandey, SA Rieder… - Future medicinal …, 2009 - Taylor & Francis
Cannabinoids are a group of compounds that mediate their effects through cannabinoid
receptors. The discovery of Δ9-tetrahydrocannabinol (THC) as the major psychoactive …

Cannabinoid CB2 receptor: a new target for controlling neural cell survival?

J Fernandez-Ruiz, J Romero, G Velasco… - Trends in …, 2007 - cell.com
Two types of cannabinoid receptor have been cloned and characterized. Whereas CB 1
receptors are ubiquitously expressed in neurons of the CNS, CB 2 receptors have been …

Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis

SD McAllister, R Murase, RT Christian, D Lau… - Breast cancer research …, 2011 - Springer
Invasion and metastasis of aggressive breast cancer cells are the final and fatal steps during
cancer progression. Clinically, there are still limited therapeutic interventions for aggressive …

Cannabis, cannabinoids and cannabis-based medicines in cancer care

DI Abrams - Integrative cancer therapies, 2022 - journals.sagepub.com
As medical cannabis becomes legal in more states, cancer patients are increasingly
interested in the potential utility of the ancient botanical in their treatment regimen. Although …

Integrating cannabis into clinical cancer care

DI Abrams - Current oncology, 2016 - mdpi.com
Cannabis species have been used as medicine for thousands of years; only since the 1940s
has the plant not been widely available for medical use. However, an increasing number of …

The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications

DM Lambert, CJ Fowler - Journal of medicinal chemistry, 2005 - ACS Publications
As far as can be ascertained from archeological sources, preparations of the hemp
Cannabis sativa L. were widely used by humans for either therapeutic or ritual purposes in …

The antitumor activity of plant-derived non-psychoactive cannabinoids

SD McAllister, L Soroceanu, PY Desprez - Journal of neuroimmune …, 2015 - Springer
As a therapeutic agent, most people are familiar with the palliative effects of the primary
psychoactive constituent of Cannabis sativa (CS), Δ 9-tetrahydrocannabinol (THC), a …

Δ9-Tetrahydrocannabinol Inhibits Cell Cycle Progression in Human Breast Cancer Cells through Cdc2 Regulation

MM Caffarel, D Sarrió, J Palacios, M Guzmán… - Cancer research, 2006 - AACR
It has been proposed that cannabinoids are involved in the control of cell fate. Thus, these
compounds can modulate proliferation, differentiation, and survival in different manners …

Cannabinoid receptor as a novel target for the treatment of prostate cancer

S Sarfaraz, F Afaq, VM Adhami, H Mukhtar - Cancer research, 2005 - AACR
Cannabinoids, the active components of Cannabis sativa Linnaeus (marijuana) and their
derivatives have received renewed interest in recent years due to their diverse …