A one-pot isothermal Cas12-based assay for the sensitive detection of microRNAs
The use of microRNAs as clinical cancer biomarkers is hindered by the absence of accurate,
fast and inexpensive assays for their detection in biofluids. Here we report a one-step and …
fast and inexpensive assays for their detection in biofluids. Here we report a one-step and …
Clinical Value of Circulating miRNA in Diagnosis, Prognosis, Screening and Monitoring Therapy of Pancreatic Ductal Adenocarcinoma—A Review of the Literature
J Wnuk, JK Strzelczyk, I Gisterek - International Journal of Molecular …, 2023 - mdpi.com
Pancreatic cancer (PC) is considered to be the seventh most common cause of cancer-
related deaths. The number of deaths caused by PC is estimated to increase in the future …
related deaths. The number of deaths caused by PC is estimated to increase in the future …
Emerging role of epigenetic alterations as biomarkers and novel targets for treatments in pancreatic ductal adenocarcinoma
MTT Roalsø, ØH Hald, M Alexeeva, K Søreide - Cancers, 2022 - mdpi.com
Simple Summary Epigenetic alterations cause changes in gene expression without affecting
the DNA sequence and are found to affect several molecular pathways in pancreatic tumors …
the DNA sequence and are found to affect several molecular pathways in pancreatic tumors …
Circulating nucleic acids as novel biomarkers for pancreatic ductal adenocarcinoma
R McGowan, Á Sally, A McCabe, BM Moran, K Finn - Cancers, 2022 - mdpi.com
Simple Summary Pancreatic ductal adenocarcinoma (PDAC) is a particularly aggressive
and deadly cancer, primarily due to failure to identify early-stage disease. PDAC is often …
and deadly cancer, primarily due to failure to identify early-stage disease. PDAC is often …
miRNAs in pancreatic cancer progression and metastasis
Small non-coding RNA or microRNA (miRNA) are critical regulators of eukaryotic cells.
Dysregulation of miRNA expression and function has been linked to a variety of diseases …
Dysregulation of miRNA expression and function has been linked to a variety of diseases …
Pancreatic Cancer Research beyond DNA Mutations
Pancreatic ductal adenocarcinoma (PDAC) is caused by genetic mutations in four genes:
KRAS proto-oncogene and GTPase (KRAS), tumor protein P53 (TP53), cyclin-dependent …
KRAS proto-oncogene and GTPase (KRAS), tumor protein P53 (TP53), cyclin-dependent …
Feature Selection and mRNA-miRNA bipartite Network Analysis for Biomarker Development and Drug Repurposing in Colon Cancer
Background: Colon cancer (CC) is the second cause of mortality among other non-skin
cancers. Despite the progression in screening and diagnostic strategies, further information …
cancers. Despite the progression in screening and diagnostic strategies, further information …
Editorial to the Special Issue “MicroRNA in Solid Tumor and Hematological Diseases”
F Lovat - Biomedicines, 2021 - mdpi.com
In the last two decades, the roles of microRNAs in the biology and progression of human
cancer have been extensively studied; at present, these small non-coding RNAs are …
cancer have been extensively studied; at present, these small non-coding RNAs are …
Alteration in Levels of Specific miRNAs and Their Potential Protein Targets between Human Pancreatic Cancer Samples, Adjacent Normal Tissue, and Xenografts …
F O'Neill, TJ Allen-Coyle, S Roche, J Meiller… - Life, 2023 - mdpi.com
Herein, we describe the global comparison of miRNAs in human pancreatic cancer tumors,
adjacent normal tissue, and matched patient-derived xenograft models using microarray …
adjacent normal tissue, and matched patient-derived xenograft models using microarray …