Prognostic significance of CD68+ and CD163+ tumor associated macrophages in head and neck squamous cell carcinoma: A systematic review and meta-analysis

G Troiano, VCA Caponio, I Adipietro, M Tepedino… - Oral oncology, 2019 - Elsevier
Abstract Objective Tumor associated macrophages (TAMs) are among the most abundant
cells of the tumor microenvironment. Several studies have been performed to investigate …

Prognostic and clinicopathological significance of PD-L1 overexpression in oral squamous cell carcinoma: A systematic review and comprehensive meta-analysis

D Lenouvel, MÁ González-Moles, I Ruiz-Avila… - Oral oncology, 2020 - Elsevier
Abstract Background The presence of Programmed Death-Ligand 1 protein (PD-L1) in oral
squamous cell carcinoma (OSCC) may indicate an ability to evade immune response and …

M2 macrophage infiltration into tumor islets leads to poor prognosis in non-small-cell lung cancer

L Cao, X Che, X Qiu, Z Li, B Yang, S Wang… - Cancer management …, 2019 - Taylor & Francis
Background: Lung cancer is the leading cause of cancer-related death worldwide. Although
the macrophages can affect the development of tumor, the contribution of macrophages to …

The immune phenotype of tongue squamous cell carcinoma predicts early relapse and poor prognosis

G Troiano, C Rubini, L Togni, VCA Caponio… - Cancer …, 2020 - Wiley Online Library
Background In patients with squamous cell carcinoma of the oral tongue (OTSCC), current
tumor node metastasis staging system fails to identify at‐risk patients associated with early …

PD‐L1 in oral squamous cell carcinoma: A key biomarker from the laboratory to the bedside

R Nocini, M Vianini, I Girolami… - Clinical and …, 2022 - Wiley Online Library
Objectives and background: Oral squamous cell carcinoma (OSCC) is a highly malignant
disease with an increasing incidence. The need to improve therapeutic strategies for …

Cardiotoxicity risk factors with immune checkpoint inhibitors

ZL Brumberger, ME Branch, MW Klein, A Seals… - Cardio-Oncology, 2022 - Springer
Background Checkpoint-inhibitor immunotherapies have had a profound effect in the
treatment of cancer by inhibiting down-regulation of T-cell response to malignancy. The …

The prognostic significance of PD-L1 and PD-1 expression in patients with nasopharyngeal carcinoma: a systematic review and meta-analysis

ZL Huang, S Liu, GN Wang, SH Zheng, SR Ding… - Cancer cell …, 2019 - Springer
Abstract Background Whether PD-L1/PD-1 expression plays a significant role in the
prognosis of NPC is still controversial. The present study mainly aimed to investigate the …

An update of knowledge on PD‐L1 in head and neck cancers: Physiologic, prognostic and therapeutic perspectives

D Lenouvel, MÁ González‐Moles, A Talbaoui… - Oral …, 2020 - Wiley Online Library
Programmed cell death‐ligand 1 (PD‐L1) is a transmembrane protein that acts as a co‐
inhibitory factor in the immune response. Its receptor, programmed cell death protein 1 (PD …

Prognostic potential of tumor-infiltrating immune cells in resectable oral squamous cell carcinoma

A Caruntu, L Moraru, M Lupu, F Vasilescu… - Cancers, 2021 - mdpi.com
Simple Summary Oral cancer is a common malignancy with high morbidity and mortality.
Tumor-infiltrating immune cells play key roles in its pathogenesis, influencing tumor …

Direct comparison of size-dependent versus EpCAM-dependent CTC enrichment at the gene expression and DNA methylation level in head and neck squamous cell …

M Zavridou, S Mastoraki, A Strati, G Koutsodontis… - Scientific Reports, 2020 - nature.com
We directly compared two different approaches used for Circulating Tumor Cell (CTC)
isolation, a size-dependent microfluidic system versus an EpCAM-dependent positive …