The expression of the reverse transsulfuration enzyme cystathionine-β-synthase (CBS) is
markedly increased in many forms of cancer, including colorectal, ovarian, lung, breast and …

The tumor microenvironment (TME) is the tumor surrounding environment, which is critical
for tumor development and progression. TME is also involved in clinical intervention and …

Metastasis is the major cause of cancer-related deaths. Neuroblastoma (NB), a childhood
tumor has been molecularly defined at the primary cancer site, however, the bone marrow …

Colorectal cancer (CRC) is a heterogeneous disease with a myriad of alterations at the
cellular and molecular levels. Kristen rat sarcoma (KRAS) mutations occur in up to 40% of …

Epidermal growth factor receptor (EGFR) mutation is the most common driver mutation in
non-small cell lung cancer (NSCLC). The first-line therapy for advanced NSCLC patients …

Hepatocellular carcinoma (HCC) is the most common primary liver cancer with a high
mortality rate. It is regarded as a significant public health issue because of its complicated …

Background The active metabolite of 5-Fluorouracil (5FU), used in the treatment of several
types of cancer, acts by inhibiting the thymidylate synthase encoded by the TYMS gene …

The role of brain immune compartments in glioma evolution remains elusive. We profile
immune cells in glioma microenvironment and the matched peripheral blood from 11 …

Colorectal cancer is a highly heterogeneous disease, with well-characterized subtypes
based on genome, DNA methylome, and transcriptome signatures. To chart the epigenetic …

Lung adenocarcinoma (LUAD) remains an incurable disease with a poor prognosis. This
study aimed to explore neutrophil‑related genes (NRGs) and develop a prognostic signature …