Heme oxygenases (HOs) act on heme degradation to produce carbon monoxide (CO), free
iron, ferritin, and biliverdin. Upregulation of cellular HO-1 levels is signature of oxidative …

Atherosclerosis is an inflammatory process of the vascular wall characterized by the
infiltration of lipids and inflammatory cells. Oxidative modifications of infiltrating low-density …

Under stressful conditions, cellular heme catabolism to carbon monoxide, iron and biliverdin
is mediated by the 32 kDa enzyme, heme oxygenase-1 (HO-1). A wide range of pro-oxidant …

Varicocele is recognized as the leading cause of male infertility because it can impair
spermatogenesis through several distinct pathophysiological mechanisms. Current …

With oxidative injury as well as in some solid tumors and myeloid leukemia cells, heme
oxygenase-1 (HO-1), the anti-oxidant, anti-inflammatory, and anti-apoptotic microsomal …

Subarachnoid hemorrhage (SAH) carries a 50% mortality rate. The extravasated
erythrocytes that surround the brain contain heme, which, when released from damaged red …

The heme oxygenases (HOs), responsible for the degradation of heme to biliverdin/bilirubin,
free iron and CO, have been heavily implicated in mammalian CNS aging and disease. In …

The heme oxygenase (HO) system is essential for heme and iron homeostasis and
necessary for adaptation to cell stress. HO degrades heme to biliverdin (BV), carbon …

Oxidative damage contributes to microbe elimination during macrophage respiratory burst.
Nuclear factor, erythroid-derived 2, like 2 (NRF2) orchestrates antioxidant defenses …

Abstract Significance: Heme oxygenase-1 (HMOX1) plays a critical role in the protection of
cells, and the inducible enzyme is implicated in a spectrum of human diseases. The …