Cell-penetrating peptides in diagnosis and treatment of human diseases: from preclinical research to clinical application
J Xie, Y Bi, H Zhang, S Dong, L Teng, RJ Lee… - Frontiers in …, 2020 - frontiersin.org
Cell-penetrating peptides (CPPs) are short peptides (fewer than 30 amino acids) that have
been predominantly used in basic and preclinical research during the last 30 years. Since …
been predominantly used in basic and preclinical research during the last 30 years. Since …
Challenge to overcome current limitations of cell-penetrating peptides
The penetration of biological membranes is a prime obstacle for the delivery of
pharmaceutical drugs. Cell-penetrating peptide (CPP) is an efficient vehicle that can deliver …
pharmaceutical drugs. Cell-penetrating peptide (CPP) is an efficient vehicle that can deliver …
Cell penetrating peptides in ocular drug delivery: State of the art
S Pescina, C Ostacolo, IM Gomez-Monterrey… - Journal of controlled …, 2018 - Elsevier
Despite the increasing number of effective therapeutics for eye diseases, their treatment is
still challenging due to the presence of effective barriers protecting eye tissues. Cell …
still challenging due to the presence of effective barriers protecting eye tissues. Cell …
Ocular therapies with biomacromolecules: from local injection to eyedrop and emerging noninvasive delivery strategies
X Fan, K Jiang, F Geng, W Lu, G Wei - Advanced Drug Delivery Reviews, 2023 - Elsevier
The last two decades have witnessed a continuously increasing number of
biomacromolecules approved for the treatment of ocular diseases. The eye possesses …
biomacromolecules approved for the treatment of ocular diseases. The eye possesses …
Delivery of various cargos into cancer cells and tissues via cell-penetrating peptides: A review of the last decade
A Shoari, R Tooyserkani, M Tahmasebi, DWPM Löwik - Pharmaceutics, 2021 - mdpi.com
Abstracts Cell-penetrating peptides (CPPs), also known as protein transduction domains,
are a class of diverse amino acid sequences with the ability to cross cellular membranes …
are a class of diverse amino acid sequences with the ability to cross cellular membranes …
Development of pH-responsive organic-inorganic hybrid nanocomposites as an effective oral delivery system of protein drugs
SH Lee, JG Song, HK Han - Journal of controlled release, 2019 - Elsevier
This research aimed to develop a pH-responsive organic-inorganic hybrid nanocomposite
as an effective oral delivery system for protein drugs. Three different nanocomposites were …
as an effective oral delivery system for protein drugs. Three different nanocomposites were …
Current progress on microrna‐based gene delivery in the treatment of osteoporosis and osteoporotic fracture
X Sun, Q Guo, W Wei, S Robertson… - International journal …, 2019 - Wiley Online Library
Emerging evidence demonstrates that microRNAs, as important endogenous
posttranscriptional regulators, are essential for bone remodeling and regeneration …
posttranscriptional regulators, are essential for bone remodeling and regeneration …
Poly (ester amide)-based hybrid hydrogels for efficient transdermal insulin delivery
Transdermal drug delivery is an attractive, non-invasive treatment. It can avoid first-pass
hepatic metabolism and provides the possibility of self-administration. Hydrogels are …
hepatic metabolism and provides the possibility of self-administration. Hydrogels are …
Topical Delivery of Cell-penetrating peptide-modified human growth hormone for enhanced wound healing
Protein drugs have been emerging as a class of promising therapeutics. However, their
topical application has been limited by their high molecular weight and poor permeability to …
topical application has been limited by their high molecular weight and poor permeability to …
Cell penetrating peptides: Highlighting points in cancer therapy
AM Asrorov, H Wang, M Zhang, Y Wang… - Drug Development …, 2023 - Wiley Online Library
Abstract Cell‐penetrating peptides (CPPs), first identified in HIV a few decades ago,
deserved great attention in the last two decades; especially to support the penetration of …
deserved great attention in the last two decades; especially to support the penetration of …