Oleate and linoleate enhance the growth-promoting effects of insulin-like growth factor-I through a phospholipase D-dependent pathway in arterial smooth muscle …

B Askari, MA Carroll, M Capparelli, F Kramer… - Journal of Biological …, 2002 - ASBMB
Diabetes causes accelerated atherosclerosis and subsequent cardiovascular disease
through mechanisms that are poorly understood. We have previously shown, using a …

Association between lipoprotein lipase polymorphism and the risk of stroke: a meta-analysis

T He, J Wang, WS Deng, P Sun - Journal of Stroke and Cerebrovascular …, 2017 - Elsevier
Background Several studies have studied the relationship between lipoprotein lipase (LPL)
Hind III gene polymorphism and stroke susceptibility. However, the conclusions remain …

Polymorphisms of the lipoprotein lipase gene are associated with atherosclerotic cerebral infarction in the Chinese

E Xu, W Li, L Zhan, G Guan, X Wang, S Chen, Y Shi - Neuroscience, 2008 - Elsevier
BACKGROUND: Lipoprotein lipase (LPL), which plays an essential role in plasma
lipoprotein metabolism and transportation, appears to be a risk factor for ischemic vascular …

[PDF][PDF] Gene therapy for genetic lipoprotein lipase deficiency: from promise to practice

MC Nierman, J Rip, J Twisk, JJM Meulenberg… - Medicine, 2005 - njmonline.nl
Lipoprotein lipase (LPL) deficiency is a rare, hereditary disorder of lipoprotein metabolism
characterised by severely increased triglyceride levels, and associated with an increased …

Predictive role of polymorphisms in interleukin-5 receptor alpha-subunit, lipoprotein lipase, integrin A2 and nitric oxide synthase genes on ischemic stroke in type 2 …

AOY Luk, Y Wang, RCW Ma, CHT Tam, MCY Ng… - Atherosclerosis, 2011 - Elsevier
OBJECTIVE: Ischemic stroke is prevalent in type 2 diabetes and may be due to metabolic,
vascular and inflammatory factors. Genetic variants implicated in these pathways may have …

DNA polymorphisms of the lipoprotein lipase gene and their association with coronary artery disease in the Saudi population

AA Al-Jafari, MS Daoud, AF Mobeirek… - International journal of …, 2012 - mdpi.com
Coronary heart disease (CHD) is a major health problem and a major cause of death in most
countries. Evidence has been presented that gene polymorphisms (Hin dIII, Pvu II and …

No evidence of accelerated atherosclerosis in a 66-yr-old chylomicronemia patient homozygous for the nonsense mutation (Tyr61→ stop) in the lipoprotein lipase …

T Ebara, M Okubo, A Horinishi, M Adachi, T Murase… - Atherosclerosis, 2001 - Elsevier
Whether chylomicronemia is atherogenic or not has yet to be determined in humans. We
investigated a 66-yr-old female with severe chylomicronemia resulting from a lipoprotein …

Functional variants of the lipoprotein lipase gene and the risk of preeclampsia among non‐Hispanic Caucasian women

C Zhang, MA Austin, KL Edwards, FM Farin… - Clinical …, 2006 - Wiley Online Library
Hypertriglyceridemia is an important pathophysiologic feature of preeclampsia, a common
vascular disorder of pregnancy. Three well‐documented functional variants (N291S, S447X …

Novel LPL mutation (L303F) found in a patient associated with coronary artery disease and severe systemic atherosclerosis

Y Saika, N Sakai, M Takahashi… - European journal of …, 2003 - Wiley Online Library
Background Patients with lipoprotein lipase (LPL) deficiency had been generally thought to
be spared accelerated atherosclerosis in spite of a marked elevation of plasma triglyceride …

The lipoprotein lipase gene in combined hyperlipidemia: evidence of a protective allele depletion

SF Wung, MV Kulkarni, CR Pullinger, MJ Malloy… - Lipids in health and …, 2006 - Springer
Abstract Background Lipoprotein Lipase (LPL), a key enzyme in lipid metabolism, catalyzes
the hydrolysis of triglycerides (TG) from TG-rich lipoproteins, and serves a bridging function …