Genetic polymorphisms, lipoproteins and coronary artery disease risk
PJ Talmud, SE Humphries - Current Opinion in Lipidology, 2001 - journals.lww.com
Association studies between gene variants (polymorphisms) and measured intermediate
phenotypes, such as lipid/lipoprotein levels, or disease endpoints such as coronary artery …
phenotypes, such as lipid/lipoprotein levels, or disease endpoints such as coronary artery …
Adeno‐associated virus‐mediated expression of acid sphingomyelinase decreases atherosclerotic lesion formation in apolipoprotein E−/− mice
AJ Leger, LM Mosquea, L Li… - The Journal of Gene …, 2011 - Wiley Online Library
Background The secretory form of acid sphingomyelinase (ASM) is postulated to play a key
role in the retention and aggregation of lipoproteins in the subendothelial space of the …
role in the retention and aggregation of lipoproteins in the subendothelial space of the …
Lipoprotein lipase gene variants and the effect of environmental factors on cardiovascular disease risk
PJ Talmud, JW Stephens - Diabetes, Obesity and Metabolism, 2004 - Wiley Online Library
Coronary heart disease (CHD) is a major cause of mortality in the Western world. CHD risk
is known to be modified by both genetic and environmental factors. In this review, we look at …
is known to be modified by both genetic and environmental factors. In this review, we look at …
Regulation of smooth muscle cell accumulation in diabetes-accelerated atherosclerosis
B Askari, CB Renard, KE Bornfeldt - Histology and histopathology, 2002 - digitum.um.es
Diabetes leads to accelerated formation/progression of lesions of atherosclerosis.
Cardiovascular disease thus develops earlier in people with type 1 or type 2 diabetes …
Cardiovascular disease thus develops earlier in people with type 1 or type 2 diabetes …
Hydrolysis products generated by lipoprotein lipase and endothelial lipase differentially impact THP-1 macrophage cell signalling pathways
Y Essaji, Y Yang, CJ Albert, DA Ford, RJ Brown - Lipids, 2013 - Springer
Macrophages express lipoprotein lipase (LPL) and endothelial lipase (EL) within
atherosclerotic plaques; however, little is known about how lipoprotein hydrolysis products …
atherosclerotic plaques; however, little is known about how lipoprotein hydrolysis products …
Lipoprotein Lipase Activator NO‐1886
W Yin, K Tsutsumi - Cardiovascular drug reviews, 2003 - Wiley Online Library
Lipoprotein lipase (LPL) is a rate‐limiting enzyme that hydrolyzes circulating triglyceride‐
rich lipoproteins such as very low‐density lipoproteins and chylomicrons. A decrease in LPL …
rich lipoproteins such as very low‐density lipoproteins and chylomicrons. A decrease in LPL …
Carriers of the frequent lipoprotein lipase S447X variant exhibit enhanced postprandial apoprotein B-48 clearance
MC Nierman, J Rip, JA Kuivenhoven, DH van Raalte… - Metabolism, 2005 - Elsevier
The frequent lipoprotein lipase S447X variant (LPLS447X) is firmly associated with a lower
incidence of cardiovascular disease, the mechanisms for which remain to be established. To …
incidence of cardiovascular disease, the mechanisms for which remain to be established. To …
Endothelial lipase mediates HDL levels in normal and hyperlipidemic rabbits
J Zhang, Y Yu, K Nakamura, T Koike… - … of atherosclerosis and …, 2012 - jstage.jst.go.jp
Aim: Existing evidence suggests that endothelial lipase (EL) plays an important role in high-
densitylipoprotein (HDL) metabolism. Because rabbits are a useful animal model for the …
densitylipoprotein (HDL) metabolism. Because rabbits are a useful animal model for the …
Monocyte gene-expression profile in men with familial combined hyperlipidemia and its modification by atorvastatin treatment
G Llaverias, J Pou, E Ros, D Zambón, M Cofán… - …, 2008 - Taylor & Francis
Aim: The genetic origin of familial combined hyperlipidemia (FCH) is not well understood.
We used microarray profiling of peripheral blood monocytes to search novel genes and …
We used microarray profiling of peripheral blood monocytes to search novel genes and …