Brain tumours and Gliomas, in particular, are among the primary causes of cancer mortality
worldwide. Glioma diagnosis and therapy have not significantly improved despite decades …

The DNA damage response (DDR) system is a complicated network of signaling pathways
that detects and repairs DNA damage or induces apoptosis. Critical regulators of the DDR …

Glioblastoma multiforme (GBM), the most common and aggressive type of primary brain
tumor, has a mean survival of less than 15 months after standard treatment. Treatment with …

Glioblastoma (GB) is a malignant and immune-suppressed brain cancer that remains
incurable despite the current standard of care. Radiotherapy is a mainstay of GB treatment …

During a normal topoisomerase II (TOP2) reaction, the enzyme forms a covalent enzyme
DNA intermediate consisting of a 5′ phosphotyrosyl linkage between the enzyme and …

Abstract Aims H3K27M‐mutant diffuse midline glioma (DMG) is a rare and aggressive
central nervous system tumor. The biological behavior, clinicopathological characteristics …

Targeted protein degradation is a powerful tool for determining the function of specific
proteins nowadays. Survivin is the smallest member of the inhibitor of the apoptosis protein …

Proteasome inhibitors are moieties targeting the proteolytic activity of a proteasome, with
demonstrated efficacy in certain hematological malignancies and candidate drugs in other …

Background The high degree of intratumoral genomic heterogeneity is a major obstacle for
glioblastoma (GBM) tumors, one of the most lethal human malignancies, and is thought to …

Glioblastoma (GBM) is the most aggressive and common primary malignant brain tumor with
limited available therapeutic approaches. Despite improvements in therapeutic options for …