Type 2 diabetes diagnosed in childhood or early adulthood is termed early-onset type 2
diabetes. Cases of early-onset type 2 diabetes are increasing rapidly globally, alongside …

Type II diabetes mellitus (T2DM) is a chronic metabolic disease characterized by prolonged
hyperglycemia and insulin resistance (IR). Its incidence is increasing annually, posing a …

Importance Youth-onset type 2 diabetes is associated with early development of chronic
complications. Treatment of elevated blood pressure (BP), nephropathy, and dyslipidemia …

Prediabetes, the precursor of type 2 diabetes mellitus, is an intermediate stage between
normal glucose homeostasis and overt diabetes. This asymptomatic metabolic state is …

TGF-β/Smad3 signaling plays a critical role in type 2 diabetes (T2D) and type 2 diabetic
nephropathy (T2DN), but treatment by specifically targeting Smad3 remains unexplored. To …

Diabetes represents a major public health concern with a considerable impact on human life
and healthcare expenditures. It is now well established that diabetes is characterized by a …

Sirtuins, which are NAD+-dependent class III histone deacetylases, are involved in various
biological processes, including DNA damage repair, immune inflammation, oxidative stress …

OBJECTIVE β-Cell dysfunction and insulin resistance magnify the risk of kidney injury in
type 2 diabetes. The relationship between these factors and intraglomerular hemodynamics …

Traditionally a disease of adults, type 2 diabetes (T2D) has been increasingly diagnosed in
youth, particularly among adolescents and young adults of minority ethnic groups …

Introduction Indigenous peoples in Canada face a disproportionate burden of diabetes-
related foot complications (DRFC), such as foot ulcers, lower extremity amputations (LEA) …