MASLD-Related HCC: A Comprehensive Review of the Trends, Pathophysiology, Tumor Microenvironment, Surveillance, and Treatment Options

Y Shi, E Taherifard, A Saeed, A Saeed - Current Issues in Molecular …, 2024 - mdpi.com
Hepatocellular carcinoma (HCC) represents a significant burden on global healthcare
systems due to its considerable incidence and mortality rates. Recent trends indicate an …

Defining an approach for therapeutic strategies in metabolic dysfunction-associated steatotic liver disease after liver transplantation

MS Siddiqui, M Muthiah, SK Satapathy, K Patidar… - Hepatology, 2023 - journals.lww.com
Occurrence of metabolic dysfunction associated steatotic liver (MASLD) is common following
liver transplantation (LT). MASLD can be classified as recurrent disease when it occurs in …

[HTML][HTML] Portosystemic shunting prevents hepatocellular carcinoma in non-alcoholic fatty liver disease mouse models

A Peloso, S Lacotte, Q Gex, F Slits, B Moeckli, G Oldani… - Plos one, 2023 - journals.plos.org
Background and aims Non-alcoholic fatty liver disease (NAFLD) is one of the leading cause
of hepatocellular carcinoma (HCC). This association is supported by the translocation of …

A new prognostic model for accurate assessment of hepatocellular carcinoma risk using RNA editing data and unsupervised machine learning

H Zhu, H Zhang, Y Xiong, H Li - Neurocomputing, 2024 - Elsevier
Abstract A-to-I RNA editing is a long-known driving factor to the progression of
hepatocellular carcinoma (HCC); however, its importance is often neglected in HCC …

Early detection of hepatocellular carcinoma: roadmap for improvement

J Melendez-Torres, AG Singal - Expert review of anticancer …, 2022 - Taylor & Francis
Introduction Hepatocellular carcinoma (HCC) has a poor prognosis, related, in part, to
frequent late-stage diagnosis. Improved implementation of effective HCC surveillance is …

Efficacy and perioperative safety of different future liver remnant modulation techniques: a systematic review and network meta-analysis

E Bozkurt, JP Sijberden, M Kasai, MA Hilal - HPB, 2024 - Elsevier
Background In daily clinical practice, different future liver remnant (FLR) modulation
techniques are increasingly used to allow a liver resection in patients with insufficient FLR …

[HTML][HTML] Higher risk of tumor recurrence in NASH-related hepatocellular carcinoma following curative resection

SC Chien, YJ Lin, CT Lee, YC Chiu, TC Chou, HC Chiu… - Viruses, 2022 - mdpi.com
Background: The outcomes for patients with NASH-related HCC after curative resection
have not been clarified. This study compared the overall survival (OS), time-to-tumor …

[HTML][HTML] Current challenges and future direction in surveillance for hepatocellular carcinoma in patients with nonalcoholic fatty liver disease

G Cholankeril, HB El-Serag - Seminars in Liver Disease, 2023 - thieme-connect.com
The burden for hepatocellular carcinoma (HCC) attributed to nonalcoholic fatty liver disease
(NAFLD) continues to grow in parallel with rising global trends in obesity. The risk of HCC is …

LAYN Serves as a Prognostic Biomarker and Downregulates Tumor-Infiltrating CD8+ T Cell Function in Hepatocellular Carcinoma

S Xiao, L Lu, Z Lin, X Ye, S Su, C Zhang… - Journal of …, 2024 - Taylor & Francis
Background Layilin (LAYN) represents a valuable prognostic biomarker across various
tumor types, while also serving as an innovative indicator of dysfunctional or exhausted …

[HTML][HTML] Prevalence of metabolic syndrome among patients with hepatocellular carcinoma of different etiologies: a retrospective study

DL Yang, SP Liu, HL Wang, JR Li, JY Su, MJ Li… - Infectious Agents and …, 2024 - Springer
Aims This study compared the prevalences of metabolic syndrome and of cardiac or kidney
comorbidities among patients with hepatocellular carcinoma (HCC) associated with …