Skin as an immune organ and clinical applications of skin-based immunotherapy

JA Bird, M Sánchez-Borges, IJ Ansotegui… - World Allergy …, 2018 - Springer
Background The prevalence of food allergy is increasing, and allergen avoidance continues
to be the main standard of care. There is a critical need for safe and effective forms of …

The role of regulatory T cells in epicutaneous immunotherapy for food allergy

G Liu, M Liu, J Wang, Y Mou, H Che - Frontiers in Immunology, 2021 - frontiersin.org
In recent decades, a rapid increase in the prevalence of food allergies has led to extensive
research on novel treatment strategies and their mechanisms. Mouse models have provided …

Targeted allergen-specific immunotherapy within the skin improves allergen delivery to induce desensitization to peanut

JJ Landers, KW Janczak, AK Shakya, V Zarnitsyn… - …, 2022 - Taylor & Francis
Aim: Epicutaneous immunotherapy (EPIT) with peanut has been demonstrated to be safe
but efficacy may be limited by allergen uptake through the skin barrier. To enhance allergen …

Innovative systems to deliver allergen powder for epicutaneous immunotherapy

Y Wang, Y Kong, MX Wu - Frontiers in Immunology, 2021 - frontiersin.org
Allergy is a disorder owing to hyperimmune responses to a particular kind of substance like
food and the disease remains a serious healthcare burden worldwide. This unpleasant and …

Delivery of allergen powder for safe and effective epicutaneous immunotherapy

Y Yu, MNK Kumar, MX Wu - Journal of Allergy and Clinical Immunology, 2020 - Elsevier
Background More effective and safer immunotherapies to manage peanut allergy are in
great demand despite extensive investigation of sublingual/oral immunotherapy and …

Intradermal allergen immunotherapy for allergic rhinitis: current evidence

K Atipas, D Kanjanawasee, P Tantilipikorn - Journal of Personalized …, 2022 - mdpi.com
Allergic rhinitis (AR) is an immunoglobulin E (IgE)-mediated inflammatory disease that is
induced by allergen introduction to the nasal mucosa, which triggers an inflammatory …

A microbiota-dependent subset of skin macrophages protects against cutaneous bacterial infection

YJ Park, BH Kang, HJ Kim, JE Oh, HK Lee - Frontiers in Immunology, 2022 - frontiersin.org
Microbiota is essential to the development and functional maturation of the immune system.
The effects of the gut microbiota on myeloid cells remote from the gut, especially the skin …

Dissolving microneedles for intradermal vaccination against shigellosis

Y Pastor, E Larrañeta, Á Erhard, G Quincoces… - Vaccines, 2019 - mdpi.com
Intradermal (ID) immunization is of increasing interest due to the easy accessibility and
excellent immunogenic properties of the skin. Among ID immunization methods, dissolving …

Intradermal Phleum pratense allergoid immunotherapy. Double‐blind, randomized, placebo‐controlled trial

FJ Sola Martínez, RM Barranco Jimenez… - Clinical & …, 2020 - Wiley Online Library
Background In allergology, the intradermal approach is generally used to establish an
aetiological diagnosis, with limited experience in specific allergen immunotherapy. Objective …

Different injection patterns of incobotulinumtoxinA for crow's feet: a split‐face comparative study

V Vachiramon, U Subpayasarn… - Journal of the …, 2021 - Wiley Online Library
Background IncobotulinumtoxinA has been previously used for the treatment of lateral
periorbital lines (crow's feet). However, a standardized injection technique has not been …