The dissemination of plasmid-borne antibiotic resistance genes (ARGs) in wastewater is
becoming an urgent concern. Previous studies mainly focused on the effects of coexisting …

Microfluidics is becoming a technology of growing interest for building microphysiological
systems with integrated read-out functionalities. Here we present the integration of enzyme …

The emergence of antimicrobial resistance (AMR) in bacterial pathogens represents a
global health threat. The metabolic state of bacteria is associated with a range of genetic …

Nowadays, there is a growing interest in deeply understanding biological mechanisms not
only at the molecular level (biological components) but also the effects of an ongoing …

Soils support a wide range of ecosystem services that underpin Earth system functioning. It
is therefore essential that we have robust approaches to evaluate how anthropogenic …

To break down organismal fitness into molecular contributions, costs and benefits of cellular
components must be analyzed in all phases of the organism's life cycle. Here, we establish …

Background The term 'metabolome'was introduced to the scientific literature in September
1998. Aim and key scientific concepts of the review To mark its 18-year-old 'coming of age' …

Over the last two decades, sequencing-based methods have revolutionised our
understanding of niche-specific microbial complexity. In the lower female reproductive tract …

Cellular metabolism evolves through changes in the structure and quantitative states of
metabolic networks. Here, we explore the evolutionary dynamics of metabolic states by …

Metabolomics is an essential method to study the dynamic changes of metabolic networks
and products using modern analytical techniques, as well as reveal the life phenomena and …