Multiple sclerosis (MS) is an autoimmune disease triggered by environmental factors that act
on a genetically susceptible host. It features three clinical stages: a pre-clinical stage …

Genetic predisposition to multiple sclerosis (MS) only explains a fraction of the disease risk;
lifestyle and environmental factors are key contributors to the risk of MS. Importantly, these …

Dietary interventions have not been effective in the treatment of multiple sclerosis (MS).
Here, we show that periodic 3-day cycles of a fasting mimicking diet (FMD) are effective in …

Lifestyle and environmental factors potently influence the risk of multiple sclerosis (MS),
because genetic predisposition only explains a fraction of the risk increase. There is strong …

Autoreactive T cell responses have a crucial role in central nervous system (CNS) diseases
such as multiple sclerosis. Recent data indicate that CNS autoimmunity can be mediated by …

Multiple sclerosis (MS) is traditionally seen as an inflammatory demyelinating disease,
characterized by the formation of focal demyelinated plaques in the white matter of the …

Recent findings in the animal model for multiple sclerosis (MS), experimental autoimmune
encephalomyelitis, implicate a novel CD4+ T-cell subset (TH17), characterized by the …

This article provides a comprehensive overview of the pathology of multiple sclerosis (MS),
including recent insights into its molecular neuropathology and immunology. It shows that all …

In view of disease heterogeneity of multiple sclerosis and limited access to ex vivo
specimens, different approaches must be undertaken to better understand disease …

Spinal cord injury (SCI) provokes an inflammatory response that generates substantial
secondary damage within the cord but also may contribute to its repair. Anti-inflammatory …