The microbiota-gut-brain-axis (MGBA) is a bidirectional communication network between gut
microbes and their host. Many environmental and host-related factors affect the gut …

Life expectancy has been on the rise for the past few decades, but healthy life expectancy
has not kept pace, leading to a global burden of age-associated disorders. Advancing age is …

Exposure to any number of stressors during the first 1000 days from conception to age 2
years is important in shaping an individual's life trajectory of health and disease. Despite the …

Introduction Immunosenescence is a progressive remodeling of immune functions
associated with a decreased ability of the immune system to set up an efficient immune …

Cellular senescence is characterized by irreversible cell cycle arrest in response to different
triggers and an inflammatory secretome. Although originally described in fibroblasts and cell …

Background: The process of aging and metabolism are intricately linked, thus rendering the
identification of reliable biomarkers related to metabolism crucial for delaying the aging …

Immune function changes across the life stages; for example, senior adults exhibit a
tendency towards a weaker cell-mediated immune response and a stronger inflammatory …

Aging is an inevitable phenomenon experienced by animals and humans, and its intensity
varies from one individual to another. Aging has been identified as a risk factor for …

Kidney dysfunction is particularly important in systemic organ injuries caused by aging.
Metabolomics are utilized in this study to explore the mechanism of kidney dysfunction …

In the aging process, physiological decline occurs, posing a substantial threat to the physical
and mental well-being of the elderly and contributing to the onset of age-related diseases …