Bone‐Targeted Exosomes: Strategies and Applications

J Wang, X Li, S Wang, J Cui, X Ren… - Advanced Healthcare …, 2023 - Wiley Online Library
As the global population ages, bone‐related diseases have increasingly become a major
social problem threatening human health. Exosomes, as natural cell products, have been …

Cell-free exosome-laden scaffolds for tissue repair

J Huang, J Xiong, L Yang, J Zhang, S Sun, Y Liang - Nanoscale, 2021 - pubs.rsc.org
With the development of regenerative medicine, tissue repair at the molecular, cellular,
tissue, and organ level has seen continuous improvements over traditional techniques. As …

Treatment of inflammatory bone loss in periodontitis by stem cell-derived exosomes

F Lei, M Li, T Lin, H Zhou, F Wang, X Su - Acta biomaterialia, 2022 - Elsevier
Periodontitis is the primary cause of tooth loss, but there is no effective treatment to repair
inflammatory bone loss in periodontitis. Exosomes emerge as essential paracrine factors of …

[HTML][HTML] Extracellular vesicles derived from M1 macrophages deliver miR-146a-5p and miR-146b-5p to suppress trophoblast migration and invasion by targeting …

J Ding, Y Zhang, X Cai, Y Zhang, S Yan, J Wang… - Theranostics, 2021 - ncbi.nlm.nih.gov
Rationale: Emerging evidence demonstrates that insufficient migration and invasion of
trophoblasts play critical roles in the pathogenesis of recurrent spontaneous abortion (RSA) …

[HTML][HTML] A multifunctional neuromodulation platform utilizing Schwann cell-derived exosomes orchestrates bone microenvironment via immunomodulation …

Z Hao, L Ren, Z Zhang, Z Yang, S Wu, G Liu, B Cheng… - Bioactive Materials, 2023 - Elsevier
Recent evidence highlights multifaceted biological needs to recapitulate the bone
microenvironment for bone regeneration. Neurotization has great potential for realizing multi …

A novel self-healing polydopamine-functionalized chitosan-arginine hydrogel with enhanced angiogenic and antibacterial activities for accelerating skin wound …

Z Ling, Z Chen, J Deng, Y Wang, B Yuan… - Chemical Engineering …, 2021 - Elsevier
Skin wound healing occurs via a series of orchestrated cellular and molecular events in a
highly ordered manner, in which insufficient angiogenesis and infection at the wound site …

Engineered extracellular vesicles for bone therapy

Y Jiang, J Li, X Xue, Z Yin, K Xu, J Su - Nano Today, 2022 - Elsevier
Extracellular vesicles, which are secreted by living cells and play a critical role in cellular
communication, have emerged as a promising cell-free strategy in the treatment of many …

Advances in materials-based therapeutic strategies against osteoporosis

C Lei, J Song, S Li, Y Zhu, M Liu, M Wan, Z Mu, FR Tay… - Biomaterials, 2023 - Elsevier
Osteoporosis is caused by the disruption in homeostasis between bone formation and bone
resorption. Conventional management of osteoporosis involves systematic drug …

[HTML][HTML] Engineered bacterial extracellular vesicles for osteoporosis therapy

H Liu, M Li, T Zhang, X Liu, H Zhang, Z Geng… - Chemical Engineering …, 2022 - Elsevier
Osteoporosis (OP) is a systemic bone disease characterized by reduction of bone mass and
destruction of structure, which can easily lead to fragility fractures. Over the past decade, an …

Engineering stem cells to produce exosomes with enhanced bone regeneration effects: an alternative strategy for gene therapy

F Li, J Wu, D Li, L Hao, Y Li, D Yi, KWK Yeung… - Journal of …, 2022 - Springer
Background Exosomes derived from stem cells have been widely studied for promoting
regeneration and reconstruction of multiple tissues as “cell-free” therapies. However, the …