[HTML][HTML] Bone engineering scaffolds with exosomes: a promising strategy for bone defects repair

M Zhang, Y Li, T Feng, R Li, Z Wang… - … in Bioengineering and …, 2022 - frontiersin.org
The treatment of bone defects is still an intractable clinical problem, despite the fact that
numerous treatments are currently available. In recent decades, bone engineering scaffolds …

Tailored extracellular vesicles: novel tool for tissue regeneration

L Li, P Wu, H Qian, W Xu, H Shi… - Stem Cells International, 2022 - Wiley Online Library
Extracellular vesicles (EVs) play an essential part in multiple pathophysiological processes
including tissue injury and regeneration because of their inherent characteristics of small …

[HTML][HTML] OTUB1 promotes osteoblastic bone formation through stabilizing FGFR2

Q Zhu, Y Fu, CP Cui, Y Ding, Z Deng, C Ning… - Signal transduction and …, 2023 - nature.com
Bone homeostasis is maintained by the balance between osteoblastic bone formation and
osteoclastic bone resorption. Dysregulation of this process leads to multiple diseases …

Engineered hsa‐miR‐455‐3p‐Abundant Extracellular Vesicles Derived from 3D‐Cultured Adipose Mesenchymal Stem Cells for Tissue‐Engineering Hyaline …

JG Chen, EC Zhang, YY Wan, TY Huang… - Advanced …, 2024 - Wiley Online Library
Efforts are made to enhance the inherent potential of extracellular vesicles (EVs) by utilizing
3D culture platforms and engineered strategies for functional cargo‐loading. Three distinct …

[HTML][HTML] Reconstructing avascular necrotic femoral head through a bioactive β-TCP system: From design to application

Y Lu, X Chen, X Lu, C Sun, M Li, G Chen, Z Long… - Bioactive Materials, 2023 - Elsevier
A variety of techniques have been used for treating avascular necrosis of the femoral head
(ANFH), but have frequently failed. In this study, we proposed a β-TCP system for the …

Self-assembled hyaluronic acid-coated nanocomplexes for targeted delivery of curcumin alleviate acute kidney injury

J Huang, J Guo, Y Dong, H Xiao, P Yang, Y Liu… - International Journal of …, 2023 - Elsevier
Acute kidney injury (AKI) is a pathological process with high morbidity, and drug resistance
is easy to occur due to untargeted drug therapy. Curcumin can repair acute kidney injury …

[HTML][HTML] 3D printing of dual-cell delivery titanium alloy scaffolds for improving osseointegration through enhancing angiogenesis and osteogenesis

H Zhao, S Shen, L Zhao, Y Xu, Y Li, N Zhuo - BMC Musculoskeletal …, 2021 - Springer
Background The repair of large bone defects is a great challenge for orthopedics. Although
the development of three-dimensional (3D) printed titanium alloy (Ti6Al4V) implants with …

Mechanism of vascular endothelial cell-derived exosomes modified with vascular endothelial growth factor in steroid-induced femoral head necrosis

H Wu, G Chen, G Zhang, Q Lv, D Gu… - Biomedical Materials, 2023 - iopscience.iop.org
Steroid-induced avascular necrosis of the femoral head (SANFH) is an intractable
orthopedic disease. This study investigated the regulatory effect and molecular mechanism …

Tumor cell membrane‐based vaccines: a potential boost for cancer immunotherapy

M Yang, J Zhou, L Lu, D Deng, J Huang, Z Tang… - …, 2024 - Wiley Online Library
Because therapeutic cancer vaccines can, in theory, eliminate tumor cells specifically with
relatively low toxicity, they have long been considered for application in repressing cancer …

Plant‐derived exosomes extracted from Lycium barbarum L. loaded with isoliquiritigenin to promote spinal cord injury repair based on 3D printed bionic scaffold

Q Wang, K Liu, X Cao, W Rong, W Shi… - Bioengineering & …, 2024 - Wiley Online Library
Plant‐derived exosomes (PEs) possess an array of therapeutic properties, including
antitumor, antiviral, and anti‐inflammatory capabilities. They are also implicated in defensive …