BACKGROUND: Optimal drug dosing is important to ensure adequate response to
treatment, prevent development of drug resistance and reduce drug toxicity. The aim of …

Introduction The importance of antibiotic treatment for sepsis in critically ill septic patients is
well established. Consistently achieving the dose of antibiotics required to optimally kill …

In the present study, population pharmacokinetic (PK) analysis was performed based on
meropenem data from a prospective study conducted in 114 critically ill patients with a wide …

Introduction Population pharmacokinetic studies of β-lactam antimicrobials in critically ill
patients derive models that inform their dosing. In non-linear mixed-effects modelling …

The number of pharmacokinetic (PK) models of meropenem is increasing. However, the
daily role of these PK models in the clinic remains unclear, especially for critically ill patients …

Several pathophysiological changes can alter meropenem pharmacokinetics in critically ill
patients, thereby increasing the risk of subtherapeutic concentrations and affecting …

Purpose This study aimed to investigate the pharmacokinetics and target attainment of
meropenem and compare the effect of meropenem dosing regimens in critically ill patients …

Appropriate antibiotic dosing to ensure early and sufficient target attainment is crucial for
improving clinical outcome in critically ill patients. Parametric survival analysis is a preferred …

This prospective study aimed to explore the determinants of meropenem trough
concentration (Ctrough) in patients with bacterial pneumonia and to investigate the …

Remimazolam is a novel benzodiazepine which is commonly used in procedural sedation,
but its pharmacokinetics in critically ill patients have not yet been unequivocally clarified. A …