The AAA+-type ATPase p97 governs an ever-expanding number of cellular processes
reaching from degradation of damaged proteins and organelles to key signaling events and …

Genomic alterations may make cancer cells more dependent than normal cells on
mechanisms of proteostasis, including protein folding and degradation. This proposition is …

Rupture of endosomes and lysosomes is a major cellular stress condition leading to cell
death and degeneration. Here, we identified an essential role for the ubiquitin‐directed AAA …

Abstract p97 (also known as valosin-containing protein (VCP) in mammals or Cdc48p in
Saccharomyces cerevisiae) is an evolutionarily conserved ATPase present in all eukaryotes …

The hexameric type II AAA ATPase (ATPase associated with various activities) p97 (also
referred to as VCP, Cdc48, and Ter94) is critically involved in a variety of cellular activities …

Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease, is an incurable
neurodegenerative condition, characterized by the loss of upper and lower motor neurons. It …

A number of neurodegenerative diseases have been linked to mutations in the human
protein p97, an abundant cytosolic AAA+ (A TPase a ssociated with various cellular a …

Cigarette smoke (CS) exposure is known to induce proteostasis imbalance that can initiate
accumulation of ubiquitinated proteins. Therefore, the primary goal of this study was to …

Cdc48 (also called VCP and p97) is an abundant protein that plays essential regulatory
functions in a broad array of cellular processes. Working with various cofactors, Cdc48 …

The dynamic composition of proteins associated with nuclear DNA is a fundamental property
of chromosome biology. In the chromatin compartment dedicated protein complexes govern …