Skeletal muscle deconditioning in breast cancer patients undergoing chemotherapy: current knowledge and insights from other cancers

J Mallard, E Hucteau, TJ Hureau… - Frontiers in Cell and …, 2021 - frontiersin.org
Breast cancer represents the most commonly diagnosed cancer while neoadjuvant and
adjuvant chemotherapies are extensively used in order to reduce tumor development and …

Pathophysiological mechanisms explaining poor clinical outcome of older cancer patients with low skeletal muscle mass

SMLM Looijaard, ML te Lintel Hekkert… - Acta …, 2021 - Wiley Online Library
Low skeletal muscle mass is highly prevalent in older cancer patients and affects 5% to 89%
depending on the type and stage of cancer. Low skeletal muscle mass is associated with …

Bone-muscle crosstalk: musculoskeletal complications of chemotherapy

BA Hain, DL Waning - Current Osteoporosis Reports, 2022 - Springer
Abstract Purpose of Review Chemotherapy drugs combat tumor cells and reduce
metastasis. However, a significant side effect of some chemotherapy strategies is loss of …

Exercise counteracts the deleterious effects of cancer cachexia

S Tsitkanou, KA Murach, TA Washington, NP Greene - Cancers, 2022 - mdpi.com
Simple Summary This review provides an overview of the effects of exercise training on the
major mechanisms related to cancer cachexia (CC). The review also discusses how cancer …

The role of exercise in cancer-related sarcopenia and sarcopenic obesity

A Papadopetraki, A Giannopoulos, M Maridaki… - Cancers, 2023 - mdpi.com
Simple Summary Sarcopenia is a serious clinical condition experienced by many oncology
patients as a disease and/or treatment-related adverse event that threatens their quality of …

Muscle wasting in cancer: opportunities and challenges for exercise in clinical cancer trials

CM Fairman, S Lønbro, TD Cardaci… - JCSM rapid …, 2022 - Wiley Online Library
Background Low muscle in cancer is associated with an increase in treatment‐related
toxicities and is a predictor of cancer‐related and all‐cause mortality. The mechanisms of …

Accelerated loss of lean body mass in head and neck cancer patients during cisplatin-based chemoradiation

S Lønbro, S Gam, AP Hermann, CR Hansen… - Acta …, 2023 - Taylor & Francis
Background This study investigated changes in body weight, lean body mass (LBM), fat
mass (FM), muscle strength and functional performance during radiation treatment in head …

[HTML][HTML] Restoring Skeletal Muscle Health through Exercise in Breast Cancer Patients and after Receiving Chemotherapy

I Aires, JA Duarte, R Vitorino… - International Journal of …, 2024 - mdpi.com
Breast cancer (BC) stands out as the most commonly type of cancer diagnosed in women
worldwide, and chemotherapy, a key component of treatment, exacerbates cancer-induced …

Short duration treadmill exercise improves physical function and skeletal muscle mitochondria protein expression after recovery from FOLFOX chemotherapy in male …

JL Halle, BR Counts, Q Zhang… - The FASEB Journal, 2022 - Wiley Online Library
Abstract FOLFOX (5‐FU, leucovorin, oxaliplatin) is a chemotherapy treatment for colorectal
cancer which induces toxic side effects involving fatigue, weakness, and skeletal muscle …

Electrical stimulation prevents doxorubicin-induced atrophy and mitochondrial loss in cultured myotubes

BA Guigni, DK Fix, JJ Bivona 3rd… - … of Physiology-Cell …, 2019 - journals.physiology.org
Muscle contraction may protect against the effects of chemotherapy to cause skeletal muscle
atrophy, but the mechanisms underlying these benefits are unclear. To address this …