Amyotrophic lateral sclerosis (ALS) is a fatal multisystem disease characterized by
progressive death of motor neurons, loss of muscle mass, and impaired energy metabolism …

The transcription factors Oct4, Sox2, Klf4, and c-Myc enable the reprogramming of somatic
cells into induced pluripotent cells. Reprogramming generates newly differentiated cells for …

Technological and methodological advances are enabling researchers to unravel the
genetics of ALS. Both causal mutations and genetic modifiers are viable therapeutic targets …

Amyotrophic lateral sclerosis (ALS) is characterized by selective and progressive
neurodegenerative changes in motor neural networks. Given the system complexity …

Amyotrophic lateral sclerosis (ALS) is a major life-threatening disease caused by motor
neuron degeneration. More effective treatments through drug discovery are urgently …

Abstract Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder, characterized
by progressive loss of both upper and lower motor neurons, resulting in clinical features …

Central nervous system diseases, particularly neurodegenerative disorders, pose significant
challenges in medicine. These conditions, characterized by progressive neuronal loss, have …

Introduction ALS is a fatal neurodegenerative disease for which underlying mechanisms are
incompletely understood. The motor neuron is a central player in ALS pathogenesis but …

Background Stem cell‐based therapy (SCT) is an important component of regenerative
therapy that brings hope to many patients. After decades of development, SCT has made …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with severe socio-
economic impact. A hallmark of ALS pathology is the presence of aberrant cytoplasmic …