Depression in patients with Parkinson's disease: current understanding of its neurobiology and implications for treatment

S Prange, H Klinger, C Laurencin, T Danaila… - Drugs & Aging, 2022 - Springer
Depression is one of the most frequent and burdensome non-motor symptoms in
Parkinson's disease (PD), across all stages. Even when its severity is mild, PD depression …

Depression in neurodegenerative diseases: Common mechanisms and current treatment options

CPC Galts, LEB Bettio, DC Jewett, CC Yang… - Neuroscience & …, 2019 - Elsevier
Major depressive disorder (MDD) is a highly prevalent psychiatric disorder and a major
cause of disability worldwide. This neurological condition is commonly associated with …

Depression and Parkinson's disease: current knowledge

L Marsh - Current neurology and neuroscience reports, 2013 - Springer
Depressive disturbances are common in patients with Parkinson's disease (PD) and
influence many other clinical aspects of the disease. In addition to causing inherent …

A systematic review of prevalence studies of depression in Parkinson's disease

JSAM Reijnders, U Ehrt, WEJ Weber… - Movement …, 2008 - Wiley Online Library
Prevalence rates of depressive disorders in Parkinson's disease (PD) vary widely across
studies, ranging from 2.7% to more than 90%. The aim of this systematic review was to …

Barriers to exercise in people with Parkinson disease

T Ellis, JK Boudreau, TR DeAngelis, LE Brown… - Physical …, 2013 - academic.oup.com
Background Exercise is known to reduce disability and improve quality of life in people with
Parkinson disease (PD). Although barriers to exercise have been studied in older adults …

The genetics of sex differences in brain and behavior

TC Ngun, N Ghahramani, FJ Sánchez… - Frontiers in …, 2011 - Elsevier
Biological differences between men and women contribute to many sex-specific illnesses
and disorders. Historically, it was argued that such differences were largely, if not …

Estrogen actions in the brain and the basis for differential action in men and women: a case for sex-specific medicines

GE Gillies, S McArthur - Pharmacological reviews, 2010 - ASPET
The classic view of estrogen actions in the brain was confined to regulation of ovulation and
reproductive behavior in the female of all mamamalian species studied, including humans …

Gender-related differences in the burden of non-motor symptoms in Parkinson's disease

P Martinez-Martin, C Falup Pecurariu, P Odin… - Journal of …, 2012 - Springer
Differences in the expression of non-motor symptoms (NMS) by Parkinson's disease (PD)
patients may have important implications for their management and prognosis. Gender is a …

Sex and gender differences in central nervous system‐related disorders

E Zagni, L Simoni, D Colombo - Neuroscience journal, 2016 - Wiley Online Library
There are important sex differences in the brain that seem to arise from biology as well as
psychosocial influences. Sex differences in several aspects of human behavior and …

Progression of Parkinson's disease in the clinical phase: potential markers

W Maetzler, I Liepelt, D Berg - The Lancet Neurology, 2009 - thelancet.com
Neuromodulatory or even neuroprotective therapy could soon be available for Parkinson's
disease (PD), raising the question of how we should define and measure disease …